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ACP 105

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Have you been stressing over wanting to look muscular? Working out in the gym 10 hours a week with no quick results? 

ACP 105 is probably just what you need. Millions of people all around the world struggle to achieve a perfect shredded physique. Bodybuilders are often in a persistent scout for a better product.

Steroids were once the most sorts after drug till many users started criticizing it for the detrimental effects like liver damage it caused.  Soon SARMs started gaining popularity after researchers observed it helped people suffering from bone disorders by promoting muscle development. Bodybuilders exploited this property.

SARMs like ACP 105 give you benefits of a steroid minus the side effects.Skip the review part. Take me to SARMS official website


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Nine years ago, a company – Acadia Pharmaceutical Inc had developed a Selective Androgenic Receptor Modulator (SARM) called ACP 105. This SARM is a partial agonist which was primarily created as a potential treatment for bone degenerative disorders like osteoporosis and arthritis etc. It is greatly known for its highly powerful efficiency in promoting an increase in muscle mass.

ACP 105 is one of the best, potent and yet safest means to help you gain lean muscle, endurance and strength. And what makes it stand out is the lack of harmful side effects.

How? Keep reading.

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ACP, like other SARMs, though maybe not as potent comes with multiple benefits. It being a partial agonist actually is a plus point.

  • It urges the body to get rid of the abnormal fat. Our body has three types of fats, namely, reserve fat, structural fat and the abnormal fat. The latter is unhealthy. ACP 105 works in such a way that this stubborn fat gets utilized and burnt.
  • Prevents muscle wasting and promotes muscle growth. This property is what makes it a suitable product for possibly curing osteoporosis and other bone disorders.
  • Helps in quick recovery from injuries and exhaustion.
  • ACP 105 provides your body with immense energy and stamina. Meaning you have longer endurance and hence can workout for extra hours without getting tired easily.
  • Greatly enhances memory and cognitive skills by increasing the levels of Androgenic Receptors (AR) in the hippocampus region.
  • Though as a SARM it is comparatively less potent, ACP 105 starts working from its very first dose. You can notice a significant gain in lean muscle mass in just a weeks’ time. You can gain 8 – 10 lbs in only 30 days.
  • The drug is 66% stronger than all popular testosterone pills.
  • It is many times safer than androgenic anabolic steroids.
  • A potential cure for breast cancer, prostate cancer and cachexia.
  • Does not cause any water retention since it does not aromatize.

It is clear how beneficial ACP 105 is. It is for the same reason ACP has gained popularity among the athletes and bodybuilders. Visit SARMS website to know more


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Every body enhancer comes with side effects. Now what we want is a product with the least side effects and effects that are relatively harmless. So what are the downsides of using ACP 105?

  • A mild headache. It usually occurs when you first begin using the product. As soon as your body gets used to the drug, it stops. A higher than advised dose and using it for longer periods will leave a constant headache though (quite obvious)
  • Little suppression in the testosterone levels. This usually begins from the 7th or 8th week of use. This is when you need to stop the cycle and go for a Post Cycle Therapy (PCT)
  • You may experience fatigue and nausea.
  • User may feel exhausted quicker in the 7th or 8th week.

None of the side effects are permanent and are all reversible. Once you go for the PCT cycle, your body gets refreshed. And this time stronger, thanks to ACP 105. This shows that ACP is so much safer than anabolic steroids like Dbol, Winstrol, Clenbuterol and Deca Durabolin. Steroids cause very harmful irreversible symptoms like damage to the liver and kidneys, shrinkage of the testicles and abnormal hair growth in both men and women.

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ACP 105, like other SARMs work by mimicking the role of the androgen – testosterone. It selectively binds with the androgen receptors (AR), working uniquely on each one of them. This ensures that it only does the necessary work and does not cause damage to vital organs and functions.

ACP 105 reduces the High Density Lipoproteins while increasing the fat free mass. This is how you grow muscles but don’t get obese. Lack of aromatization ensures there is no elevation in estrogen levels, hence no water retention.

It interferes with the negative feedback loop of the Hypothalamus – Pituitary axis. This results in an increase in testosterone levels. This is why using SARMs for longer periods disrupt the hormonal balance and causes a testosterone suppression. A PCT corrects this easily.

Thus, ACP does the necessary work. You have achieved muscle growth while maintaining a healthy weight. Your body looks shredded, fit and healthy.

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We advise you to take the product after a meal and at least half hour before you hit the gym (or workout at home).

Women: Taking 5 mg per day for 8 weeks does the required work.

Men: 10 mg per day for 8 – 12 weeks is just the right duration for desired results.

Please do not use more than advised. You obviously don’t want side effects to kick in.

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While ACP 105 alone can help you with both bulking and cutting, SARMs are generally stacked to give you an enhanced benefit of each SARM used. These stacks work faster and more efficiently.

Bulking

Stacking ACP 105 with Ligandrol LGD 4033 is perhaps one of the best bulking stacks. You may also go for MK 677.

Cutting

Ostarine MK 2866 when stacked with any SARM is an excellent option. It promotes fat loss higher than any other product. So stacking it with ACP 105 is definitely our favorite.

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ACP 105 essentially does require a PCT. After using it for 7 – 8 weeks, a testosterone suppression is observed. In addition, you start feeling easily exhausted and may feel nauseated too. This is the signal that you now need to stop using the SARM and begin the PCT cycle.

Since ACP 105 is not  a very potent product, it does not require using powerful PCTs like Clomid or Nolvadex.  A certain product called Red PCT is made from only natural ingredients. Contents like Bisporus, Luteolin, Resvaratrol, Grape Seed Extract and some other natural extracts make it the healthiest option. Using it for 4 weeks will do the needful.

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SARMs should always, with no exception, should be bought from a trustworthy reliable source.

SARMs store is a website that sells pure products.

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“If you ask me what should you use to gain a shredded body, I’d undoubtedly recommend ACP 105. Hitting the gym has always been a hobby but I’d be too embarrassed after failing to workout for more than only an hour. Also I couldn’t really notice much of any development. I was almost about to opt using steroids when my gym instructor asked me not to, ya know, the detrimental effects of using them. So I ordered a particular SARM called ACP 105 instead. I can give 10/10 to this product from my bottom of my heart. Max Cullen A remarkable product with excellent results. I not only developed shredded lean muscle, I can now workout for hours. I feel healthy and always energized. The only side effect I personally experienced was a headache which would go away pretty quick. So I’d definitely rate it a perfect 10/10.” Mark I am a girl and am an avid basketball player. As the saying goes ‘Practice makes a man perfect”, I live by that. Lately I’ve become lethargic and don’t even go for practice sessions. I started feeling concerned and came across SARMs, a product that athletes frequently use to practice extra hours. Now I know it is banned to be used before a game but I’d totally require it for my practice sessions and that’s what I did. Ordered one called ACP 105. Used. Felt I’ve been charged with extra energy. I am so happy I don’t miss a single practice session now and in fact I don’t stop playing till I really should. Thanks ACP 105, you are helping me do what I love. Alexis Grayson

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Q. Is ACP 105 a legal product?

A. Despite all its positive benefits, the Food and Drugs Administration (FDA) has not approved ACP 105 or any SARMs yet. They are still under research and are unclear about long term effects on our body. But with what users have reported till date, none have experienced any harmful irreversible effects. It is safe to say that SARMs are definitely not going to harm you as long as you take doses as per advised. Q. Why choose SARMs over anabolic steroids?

A. Anabolic steroids are extremely potent and sure give you muscle growth faster than an other existing product but it is infamous for its permanent and harmful effects on one’s body. Steroids interfere with vital functions and damages the liver and sometimes the kidneys. Males develop breasts and there have been reports of men experiencing a shrinkage of testicles. While some go bald, some develop hair growth at abnormal places (both men and women).
On the other hand, SARMs work selectively on the Androgen receptors and only interferes with the negative feedback loop of the Hypothalamus to increase Testosterone levels. This ensures that none of your vital organs gets effected. You may notice Testosterone suppression, headache and nausea – all of which are only temporary. Once you start PCT, everything gets normal.
It is clear as day that SARMs are safer than anabolic steroids. Q. Can I stack ACP 105 with RAD 140?

A. Yes, you absolutely can. In fact, you can stack ACP 105 with any SARM you want. Users experiment and keep changing stacks to see which one works best for them. You have the freedom to switch stacks and decide what works best for you. Q. Can a heart patient use SARMs?

A. SARMs are still under research and we do have a scientific statement as to how exactly does these effect your health. So whatever we say, take it with a grain of salt. You might want to consult a doctor or physician if you are a heart patient willing to use SARMs. Q. I am diabetic. Can I use SARMs?

A. Some users report saying that using SARMs has helped improve the sugar levels. That being said, we do not have a scientific study stating this. So please do consult a doctor or physician before you start using any SARMs. Q. Which is the best SARM for muscle growth?

A. We do not have an exact answer. Some may RAD 140 is the best, some say MK 2866 is and some others might say nothing can beat ACP 105. What we know is, this depends completely on the user. Every person’s metabolism is different and so is the effect of each drug on one’s body. But yes, you can be sure that no SARM is going to harm you. You are free to experiment by changing the SARM you use each cycle.

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ACP 105 is undoubtedly an excellent product when it comes to help you get muscular, stronger and healthier. Although it is a relatively lesser potent SARM, taking it in the right doses while also following a proper diet and exercise schedule gives you the results you desire. ACP 105 is both a good bulking and cutting product. But why not aim for the best? Stacking SARMs enhances the benefits and so is a popular culture among Bodybuilders and athletes.

It is important to keep in mind that SARMs are not approved by the FDA. Therefore it is advisable to talk to a physicist or a doctor prior starting the dose. Always stick to the recommend dose.

Following the rules and keeping yourself healthy will let you achieve the reward in no time. Now that you know everything you need to know, what more are you waiting for? Let your body be as strong as you are with ACP 105 today.

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S 23

S23 is one of the most potent and powerful SARMs (Selective Androgen Receptor Modulators) on the market. The one following S23 is YK11. We will talk about the benefits, side effects and recommended dosages.

Keep in mind that S23 is only meant for research purposes and isn’t approved for human consumption. In Australia, it’s considered to be a Schedule 4, prescription only compound.

Table of Contents

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S23 is a SARM (Selective Androgen Receptor Modulator)

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S23, like other SARMs, works basically in the same way anabolic steroids do with the exception that SARMs are selective. This means that unlike steroids this SARM will only target androgenic receptors in our muscle tissue and won’t cause side effects like steroids who affect receptors in our prostate as well.

This means that S23 and other SARMs will work very similarly to steroids and won’t have that many side effects. Of course, SARMs are on average much weaker than steroids are but this compound is actually very strong and is comparable to steroids in power. S23 and YK11 are the strongest out of SARMs on the market so far.

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This compound has a lot of lucrative benefits, but keep in mind that it isn’t fully researched yet and is still currently undergoing research. Other SARMs like Ostarine or LGD 4033 are a lot more researched and safe.

The benefits of S23 are:

  • Increased muscle mass
  • Increased strength
  • Fat loss
  • Boosted endurance
  • Reduced recovery times

Now let’s go over each benefit individually and explain it in detail.

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This is the reason why people are even talking about S23. You will see insane muscle gains with this SARM. The effectiveness at which S23 promotes muscle growth is even comparable to strong steroids. This is why some people call S23 a weird hybrid between SARMs and steroids. Needless to say, we don’t recommend a compound like this to a beginner because your body won’t be able to handle something like this.

Remember, training and diet are still the most important parts. Even though S23 is very strong, it won’t do anything without at least somewhat proper training and nutrition. Also, if you don’t continue to train after the cycle, you will most likely lose most of your gains.

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S23 also has a powerful benefit of increasing your strength. The strength gains will also be insane and comparable to the ones you would get on a normal steroid cycle.

People who use S23 report incredible strength gains. They get stronger week after week and are easily able to frequently break their PRs (personal records). According to them, it is not uncommon that they get over 50lbs on their major lifts, bench press, deadlift and squat, over the cycle.

When it comes to keeping that kind of strength, take that with a grain of salt. You most likely won’t be able to keep all of the strength gains, but with proper training after the cycle, you might be able to keep most of them.

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S23 promotes fat loss, not as successfully that Stenabolic or Cardarine do, but it still does pretty well. This means that you will be able to gain muscle and lose fat at the same time. You will even be able to lose some fat when on a small caloric surplus.

Along with this, people also report that they look a lot more vascular during their cycles. They also get a lot better pumps in the gym that last a lot longer.

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S23 will to some extent also give you better endurance. It won’t be as powerful at this as some other compounds but it will still be noticeable. You will be able to work out for longer periods of time and won’t need to take so many breaks between sets.

People also report that it gives you more stamina in the bedroom as well. This makes sense because it is also being currently researched as a “male birth control pill”.

Another thing that S23 will do is it will reduce your recovery times. Usual recovery times after a hard gym session is 72 hours. People who take S23 report that their recovery times went down to less than a day. This will allow you to workout hard more frequently and because of this, you will get better results.

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S23Steroids
Build MuscleBuild Muscle
Shred FatShred Fat
Low Side EffectsMedium to high Side Effects
Medium Aromatization High Aromatization

S23 is actually quite comparable to most steroids in strength and if you follow a correct PCT you won’t be seeing any side effects from this SARM. At least this is what we know so far, the compound is still not fully researched.

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So far we only know of one side effect, suppression of your natural Testosterone production. Actually, all SARMs suppress your Testosterone production but S23, in particular, does it a lot more than the others. We don’t recommend a PCT (Post Cycle Therapy) for most SARMs, the only exceptions are S23 and YK11 possibly as well.

This compound is so strong that your body will need a long time after the cycle to recover naturally. At that time you will experience bad effects of suppressed Testosterone like brain fog, bad mood, etc.

If you want to avoid a PCT, keep your dosages very low and it should be ok. But we recommend that you chose another SARM to be safe.

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We recommend that you start with a dosage of 5mg a day and based on your results work your way up to 15mg a day. You should remember, S23 has a half-life of 12 hours, this means that you should split your daily dosage into 2 parts and take the first in the morning and the second in the evening. For example, a good cycle would be 2.5mg in the morning and 2.5mg in the evening for an 8-week cycle.

We don’t recommend that you have your cycle for over 8 weeks.

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S23 is actually the only SARM (possibly YK11 as well) with which we recommend that you do a PCT ( Post Cycle Therapy).

This is because of how potent and powerful this SARM actually is. We recommend that you do a 4 week PCT of either Nolvadex or Clomid at the end of your cycle.

If you don’t want to do a PCT, we recommend that you take a dosage of 5mg maximum.

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In conclusion, this compound is a very strong SARM and you will see really good results from it. This compound isn’t fully researched yet so this is definitely a big downside. There may be some side effects that we don’t know so far. We definitely recommend that you try out or research other SARMs first before trying out S23. Other SARMs are a lot more researched and some are even successfully completing clinical trials (Ostarine and LGD-4033).

Make sure to take very small dosages if you want to avoid a PCT.

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S23 is a SARM (Selective Androgen Receptor Modulator). It is one of the strongest and most potent on the market along with YK11.

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S23 works similar to how steroids do, the difference is that it is a SARM and is selective to which androgen receptor it binds. This way it avoids causing side effects that steroids cause.

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S23 will have great benefits such as fat loss, incredible lean muscle gain, increased bone health and better endurance. A suggested dose is 5mg a day, split into two parts.

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The recommended dosage is between 5mg to 15mg per day, split into two parts. Take one part in the morning and the second in the evening.

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S23 has a half-life of 12 hours, this means that we have to take it in two parts, first in the morning and second in the evening.

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YK 11

YK11 is known as one of the strongest SARMs (Selective Androgen Receptor Modulators). Some people even compare it to steroids because of how powerful this compound is. In this article, we will go over everything about YK11. This includes the YK11 benefits, side effects, dosages, example results as well as where to buy this compound and more.

Let’s get right into it. Firstly, let’s explain what YK11 actually is.

Table of Contents

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YK11 is a steroidal SARM (Selective Androgen Receptor Modulator). More specifically, it’s a Myostatin inhibitor. It’s considered to be one of the most powerful SARMs on the market and it’s actually comparable to certain steroids in its effectiveness.

Because it’s a SARM, it binds itself to our androgen receptors. Unlike steroids, SARMs are selective. This means that they choose which androgen receptor to bind on so that we can get all the benefits of when they bind to muscles and no side effects that steroids cause (prostate problems etc.).

But YK11 is also a Myostatin inhibitor. This is actually the main reason why it’s getting so much attention and popularity lately. Let’s explain what this is and how YK11 actually works.

The YK11 molecule

YK11 is also a myostatin inhibitor (myostatin reduces our muscle mass), which means that you won’t be losing muscle while cutting and will very likely gain some instead, making it a great compound for cutting, lean bulking and especially body recomposition.

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As we said, YK11 is a Myostatin inhibitor. It’s important that we know what Myostatin and Follistatin are to understand how YK11 works.

Myostatin is a protein that reduces muscle mass in our bodies as well as our strength. Follistatin is the antagonist of Myostatin, it increases our muscle mass and strength. Basically, Follistatin keeps Myostatin in place and promotes muscle growth. Myostatin, on the other hand, blocks muscle growth.

YK11 aims to increase our Follistatin levels by inhibiting our Myostatin. Because it inhibits the Myostatin, it’s very effective at keeping our muscle mass because Myostatin can’t promote muscle loss. The results of this are increased levels of Follistatin which very effectively promote great muscle gains.

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When it comes to the legality of YK11, it all really comes down to the legality of SARMs. Basically, SARMs are legal to buy and use in every country in the world. The only exception is Australia, we will talk about that later.

Everywhere else, however, you don’t have to worry about getting into trouble for using compounds like YK11. Remember, however, that YK11 is only meant for research purposes and isn’t approved for human consumption.

If you want more information about this subject, read my article on the legality of SARMs.

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When it comes to Australia, the laws regarding SARMs are different from the rest of the world.

In Australia, you aren’t allowed to use SARMs without a doctor’s prescription. This is because YK11 and other SARMs are considered to be Schedule 4 prescription only compounds by the TGA.

You can read more about this subject in my article on Australia SARMs.

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Almost all sports bodies, including the Olympics, listed YK11 as a prohibited substance because of the unfair advantages that it gives (increased muscle mass, strength, etc.). It’s listed as a banned substance by the WADA (World Anti Doping Agency) and the USADA (the United States Anti Doping Agency).

Don’t use this compound if you are a competing professional athlete.


If you want more information on the legality of YK11 and other SARMs, read our article where we answer this question in detail- are SARMs legal.

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It’s very, very powerful. One of the most powerful SARMs on the market, the only one that can be compared to it is S23. It’s so strong that it can be compared to steroids in muscle growth as well as strength gains.

YK11 blows other strong SARMs like RAD140 and LGD 4033 out of the water.

However, with few human or animal studies to back these claims, it could be a bit difficult to tell how accurate the claims are. Most of what we know so far about is based on the experiences of those who used it.

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Sadly, the only studies that were done on this compound so far were cellular studies.

So far, (checked in March of 2020) there weren’t any animal studies or clinical trials done on this compound. All of the evidence/knowledge that we have about it is from the cellular studies and the anecdotal evidence from people using it.

We also know quite a bit about YK11 because it has similar properties that other SARMs with a lot more research have. There are a lot of people that cycle this compound and report good results. We will go over what other people report later in the article.

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Most likely, this is what you are the most interested in when it comes to this compound. Let’s go over the benefits.

The benefits are:

  • Increased muscle growth
  • Strengthened bones
  • Increased strength

Now let’s go over each benefit in more detail.

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YK11 has an incredible ability to increase your lean muscle mass. Out of every other SARM on the market right now, YK11 will result in the biggest muscle gain during a cycle.

The reason YK11 helps build muscle so well is that it blocks Myostatin (a protein that reduces muscle) and shoots up Follistatin levels (Follistatin promotes muscle gain). This results in an incredible ability to increase lean body mass when bulking and preserve your muscle when cutting.

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With the research we have right now, we have seen that YK11 shoots up the amount of activated PKB (Protein Kinase B) in the body. PKB is responsible for the growth of bone cells. This means that YK11 supports bone health and reduces bone breakability.

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People who take YK11 report incredible strength gains along with the muscle gains. They are able to consistently get stronger week after week and break their bench press, squat and deadlifts by up to 50 pounds each during a cycle.

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People who took YK11 and stuck to the recommended report incredible muscle and strength gain and very little side effects. Some people still report side effects such as:

  • Hair-loss (Most people who report this got their “lost” hair back in a few weeks after the cycle, suggesting that the reason hair-loss / hair shedding occurred in the first place was due to them being nervous and stressed during the cycle.)
  • Mild acne (Most people lose acne after the cycle, suggesting that the reason they got it was due to the stress.)
  • Increased aggression
  • Lower libido (This is due to the testosterone suppression that YK11 causes. Libido will return to normal a few weeks after the cycle)
  • Gyno (This is very, very rare and only happens to people who take dosages close to 40mg a day and keep their cycle up for over 12 weeks.)

It is also worth noting that YK11 does not cause liver damage up to a 30mg dosage. After that, the substance can become toxic to the body and make unnecessary damage to the liver or other organs.

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Most bodybuilders say that they get great results by taking a dosage of 10 to 15mg per day and see very little side effects when taking a dosage like this for the length of 8 weeks. We recommend if you are inexperienced with SARMs to take a dosage of 5mg YK11 per day for a length of 6 to 8 weeks. Your body will see great improvement when taking a dosage like this, especially if you are not close to your genetic limit yet.

Here are two examples of YK11 cycles, example 1 is meant for a beginner with SARMs and example 2 is meant for people who had previous SARMs experience. These two cycles are very safe, will provide great results and no side effects if you stick to them.

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The research so far tells us that the half-life is 12 hours. This means that in order to keep YK11 levels in our body optimal, we should split our dosage into two parts and take one in the morning and the second one in the evening.

For example, if your dosage will be 5mg per day, you should take 2.5mg in the morning and 2.5mg in the evening. Doing this will get you the best results possible out of your cycle.

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In short, no it cannot. Real, pure SARMs don’t cause hair loss, prohormones that are in some bunk products do. Read more about this subject in my article on SARMs hair loss.

I recommend you buy SARMs from good, trusted vendors like this company to avoid side effects like hair loss.

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I don’t recommend that you stack YK11 with other SARMs. This is because it’s one of the strongest SARMs on the market and stacking it with other, weaker SARMs would be a waste. There are only so many androgen receptors available in your body. Stacking YK11 with another SARM would just waste some of these receptors because the other SARM would bind to some of them.

Another reason why this is a bad idea is suppression. YK11 is already suppressive, you don’t want to raise that suppression by adding more suppressive compounds.

At the end of the day, it’s safer and more effective to just cycle YK11.

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There are a few compounds that would do very well if you stacked them with YK11. These compounds are MK 677, Cardarine and SR 9009.

These three compounds are non-hormonal (non-suppressive) so they are great when stacked with SARMs. If you want to lose fat, I recommend that you add Cardarine or SR9009 to your stack and if you want to bulk up, add MK 677.

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When it comes to the question PCT or no PCT, you really have to know if you are suppressed or not. The only 100% certain way of knowing if you are suppressed enough to need to do a PCT (Post Cycle Therapy) is by getting your blood work done.

A good rule of thumb is that you don’t need a PCT for any SARM because they aren’t that suppressive, this includes YK11. Your body will recover naturally in a few weeks after the cycle if your compounds are high-quality and pure.

Sometimes, companies sell bunk products that are way more suppressive than they should have been so that is why some people get suppressed from SARMs.

As we said, the only way to 100% certainly know if you are suppressed is by getting a blood test done. Another way of knowing, though not as reliable, is to see how you are feeling. If you feel like sh*t and have no energy and just want to sleep all day then yeah, you are probably suppressed. If you don’t feel like that, however, you almost certainly aren’t suppressed.

Your body will recover naturally if you use real, high-quality, pure YK11 and stick to normal dosages and cycle length.

If you still want to do a PCT, here is an example of a YK11 PCT.

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Here are two PCT (Post Cycle Therapy) YK11 protocol examples. Keep in mind that this is assuming that your cycle lasts 8 weeks. So if the PCT says to take 20mg of Nolvadex or Clomid a day from week 6-9 this means that you should start at the 6th week of your YK11 cycle and continue it for 2 weeks after the cycle (cycle lasts 8 weeks).

PCT protocol for YK11 if you don’t feel suppressed and want to do it to be safe:

WeekNolvadex/Clomid
6-9 (4 weeks)20mg a day

PCT protocol for YK11 after obvious suppression:

WeekNolvadex/Clomid
6-7 (2 weeks)40mg a day
8-9(2 weeks20mg a day

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If you want to get information about this compound in video format, check out this video. It’s obviously not as in-depth as this article, but it’s decent nevertheless.

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To get the best possible results from your cycle without side effects, you should buy high-quality, pure YK11. A lot of people experience weird side effects because their products are bunk and have other substances mixed into them.

Even though I haven’t done a YK11 cycle before, I have cycled almost all other SARMs and I can confidently recommend this company (click the button). I even talked to people who tested their YK11 and all of them report great results and are very satisfied with what the compound that they bought.Buy high quality, pure YK11


And the best thing about this company? They have a 30-day money-back guarantee policy. So if you aren’t satisfied with the benefits, you can get your money back. Basically, you can’t go wrong with them.

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In conclusion, YK11 is one of the most powerful SARMs currently available on the market. The strength and muscle gains from this compound are comparable to the ones you would get from certain anabolic steroids. It’s a lot stronger than some strong SARMs like LGD 4033 or RAD140.

Keep in mind, there aren’t a lot of studies done on YK11 and so far there aren’t any clinical trials either. Still, a lot of people cycle it and report good results. The best thing you can do to get good results and to avoid side effects when cycling YK11 is to make sure that you buy high-quality and to stick to normal dosages as well as a normal cycle length.

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MK 677

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This is the best review and guide for MK 677, also called Ibutamoren or Nutrobal.

You will find this guide very useful, if you have questions similar to these:

  • Is MK 677 legal
  • What is MK 677 and how does it work
  • What are the benefits and side effects of MK 677
  • Where to get the highest quality and purest MK 677 for sale
  • What is the half-life of Ibutamoren and what is the best time to take it

We will answer all of these questions as well as cover other MK 677 topics such as Ibutamoren for height growth, MK 677 before and after results…

Before we begin, however, you have to remember that this compound isn’t approved for human consumption. It’s only meant for research. I am in no way promoting the use of this compound in this article or providing medical advice. You should only talk to your doctor for medical advice.

With that being said, let’s first start by explaining what MK 677 actually is and how it works.

Table of Contents

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Some people mistake MK 677 for a SARM (Selective Androgen Receptor Modulator). In reality, it’s actually not a SARM at all, it’s a growth hormone secretagogue.

This means that it will promote the production of GH (Growth Hormone) and IGF-1 (Insulin-like Growth Factor 1) in the body.

Because of this, Ibutamoren has great benefits such as:

  • Reduced body fat
  • Increased muscle mass
  • Increase skin, hair and nail quality
  • Better sleep

We will go over all of the benefits and side effects in detail later in this article.

Now, let’s go over how this compound actually works.

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As we said, MK 677 is a growth hormone secretagogue. This means that it encourages our body to produce more natural growth hormone.

More specifically, it encourages your body to produce more GH (growth hormone) and IGF-1 (Insulin-like Growth Factor 1). For those of you who aren’t familiar with IGF-1, it’s basically a mediator for growth hormone in most cells and tissue.

Gowth hormone levels will be raised to a similar level that they were when we were teenagers.

Teenagers can still take this compound, it can cause a slight growth spurt if you didn’t finish growing yet. But remember, MK 677 is a lot weaker in comparison to growth hormone shots/therapy that people with a deficiency in growth hormone take. This compound will make our body produce more natural growth hormone instead of getting the hormone from shots.

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This is another great thing about MK 677, it’s very well researched. There have been a lot of studies done on it including multiple human and animal trials. It’s not FDA (Food and Drug Administration) approved yet, but it’s getting there.

Currently, it’s in clinical trials and all studies are reporting really good news about this compound.

So to summarize, MK 677 is really well researched with a lot of studies and research backing it up. In fact, it’s even successfully going through clinical trials right now in 2020.

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Obviously it’s important to know if this compound is actually legal. It would be no use for us if Ibutamoren was this great compound but was illegal.

To make this short, yes, MK 677 is legal to buy and use anywhere in the world. An exception, however, is Australia. If you want to legally buy and use MK 677 in Australia, you will need a doctor’s prescription for it because it’s a Schedule 4 prescription only compound.

You have to remember though, that this compound is illegal for competitive athletes in professional sports because of the unfair advantages that it provides.

If you want to get more information about the legality of this compound, read our article where we answer the question; is MK 677 legal.

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We explained what MK 677 is and how it works, now let’s go over the benefits that it gives.

The benefits are:

  • Reduced body fat
  • Increased muscle mass
  • Enhanced recovery
  • Increased sleep quality
  • Increased hair and skin health

Let’s go over each benefit in detail:

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One of the great benefits of MK 677 is that it will lower our body fat over longer periods of time.

In fact, a study tested this on 40 people who volunteered for a 16-week cycle. They were closely monitored and the study found out that the ones who were taking MK 677 at 15mg a day lost 3% of their body fat over the course of 16 weeks.

This is because of the increased levels of growth hormone. It encourages the body to lose fat and instead gain muscle.

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Increased muscle mass is along with fat loss probably one of the most lucrative MK 677 benefits.

Similar to the fat loss study, there was a study on the topic of how much MK 677 increases muscle mass. A test group was given 12.5mg of Ibutamoren a day for 16-weeks and over that period of time, they gained 2lbs of muscle. Remember, that was without even training or changing up their diet.

Because of this, Ibutamoren is also a great compound to use after a SARM (Selective Androgen Receptor Modulator) or steroid cycle. It will allow us to keep the muscle gains from the cycle very easily.

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Normal recovery time after training is around 72 hours. With this compound, you can expect that to drop to about 48 hours. This is great because it will allow you to train more frequently.

But still, the reduced recovery time isn’t as reduced as it would be on a SARM cycle.

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This is the benefit that MK 677 is probably most famous for. A lot of people praise it and I agree with them, it feels amazing.

The increased levels of growth hormone will make your sleep a lot deeper. Because of this, you will feel more rested in 6 hours than you would normally in 8 hours. You will have more energy throughout the day and just feel a lot more rested.

If you want to fully experience this benefit and want to sleep like a baby, I recommend that you take your dosage about an hour before going to bed.

You should notice better sleep quality in the first two weeks of taking the compound.

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Along with the increased sleep quality, this compound is also very famous for the increased hair and nail growth and increased hair and skin quality.

People (I can confirm as well) report that their skin and hair look much better. Their hair and nails also grow faster and some people even get thicker hair from Ibutamoren.

So it isn’t very surprising when we tell you that a lot of people even take this compound as a balding prevention regime. This is because the compound increases the growth of hair follicles and promotes their healing which results in faster and thicker hair growth.

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Most people see great benefits taking anywhere from 10mg up to 25mg of MK 677 a day. Increased growth hormone levels can take a while to “kick in” so that is why it’s best to take Ibutamoren for an extended period of time.

Some people take Ibutamoren for cycles of 16 weeks, then they take a 5-week break and repeat. There are some who like this compound so much that they take it for years without taking breaks. So far the studies found no side effects when taking this compound for an extended period of time. I suggest that you do a 16-20 week cycle then take a break for at least 5 weeks.

This is because most people, including me, do this with good results and we don’t experience any side effects. Another good reason for this recommendation is because most studies and research are done around this cycle length.

A good MK 677 cycle example:

WeekMK 677
1-16 (or 1-20)20mg a day

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Ibutamoren has a half-life of 24-30 hours. Recent research confirms that the half-life is 24 hours.

This means that we can get the most optimal results by taking it once every 24 hours.

Some people take their dosage in the morning and some in the evening. When you take your dosage depends on what you want to do. People who take it in the morning usually see increased hunger and this way they can gain weight faster. Those who take it in the evening avoid the hunger effect and report amazing sleep.

You can even take it a step further and split your dosage into two parts and take the first in the morning and the second in the evening. This results in the most optimal MK 677 levels in your body, it won’t make a huge difference if you just take it once every 24 hours though.

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Stacking MK 677 with SARMs (Selective Androgen Receptor Modulators) or even anabolics is great. Most people use it on their other cycles to prevent hair loss or hair shedding and even for its amazing sleep quality effects.

In fact, a lot of people, including me, use Ibutamoren during SARM cycles. This is because it makes it easier to keep the strength and muscle mass gains from the SARM cycle.

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Ibutamoren doesn’t reduce our natural production of testosterone. Because of this, we don’t have to worry about doing a PCT (Post Cycle Therapy) after the MK 677 cycle. Great, right?

In fact, a lot of people even use this compound as a PCT after a steroid / SARM cycle. This is because it will make it easier for them to keep their muscle and strength gains.

If you want to take MK 677 as a PCT for your SARM cycle, take it from the start of the SARM cycle and continue it for 8 weeks after the cycle is over. For example, if you do 8 weeks of SARMs, start MK 677 at week 1 and end it at week 16 or 20. This way you will be able to easily keep all your gains.

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Now that we covered the benefits of this compound, let’s go over the side effects. The great thing about this compound is that it has no serious side effects, this is backed by a lot of studies and research.

An important thing to keep in mind when it comes to the side effects of this compound, this is also true when it comes to the side effects of other compounds like SARMs. Some companies sell bunk products that have other substances mixed into their products. This reduces the effectiveness of the compound and increases the side effects.

This is why I always recommend that you buy real, high-quality, pure MK 677 and other SARMs, to avoid unnecessary side effects and to get the best results from your cycle.

Possible side effects:

  • Water Retention
  • Increased hunger
  • Reduced Insulin Sensitivity (rare)
  • Headaches (rare)

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Now let’s go over the side effects in more detail:

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This is a somewhat common side effect when it comes to Ibutamoren. Most people don’t experience this compound but some do. We can easily go around this side effect by drinking more water. In fact, the reason that water retention occurs on some people’s MK 677 cycles is because they drink too little water or their diet is really bad (high sodium etc.).

So if you notice water retention on your cycle, make sure to drink more water or keep an eye on your diet. It should go away in a few days. Even if it doesn’t, this side effect is mostly harmless and it will go away in a few days – weeks after the cycle on its own anyway.

If you want more information on this topic, read our article about MK 677 water retention.

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Increased hunger is probably the most famous “side effect” of MK 677. For you, it might be a benefit, for some other people it might be a side effect.

If you want to avoid an increase in hunger, take the dosage before going to sleep. If you want to have increased hunger, take the dosage in the morning. This effect wears off in a few weeks into the cycle anyway.

You should notice an increase in hunger in the first week or two. But some people don’t even experience this, we are all different so not everyone experiences this but most people do.

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Some people report that their insulin sensitivity got reduced on their MK 677 cycle. Very few people report this, but still, some do. This could be a problem for type 2 diabetes patients.

The good news is that clinical trials have researched this by measuring blood glucose levels. It turns out that MK 677 doesn’t actually change blood glucose levels at all, proving that Ibutamoren won’t reduce insulin sensitivity.

We can assume that the few people that report this most probably have bunk products. This is a good example of why it’s so important that we buy pure compounds.

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In the first two weeks, you can expect to notice the increased sleep quality benefit as well as the increase in hair and skin quality. Around the same time, you will also notice that your hair and nails are growing faster.

Body changes, such as fat loss, lean muscle gains and strength gains as well will be noticeable at around week 10 for most people.

We recommend that you take frequent pictures of yourself for easy progress tracking.

Remember, the results are also dependent on the work you put into your training and the dedication to your diet.

If you want to read some MK 677 reviews from real people to give you a better idea of what to expect from your cycle, read our article about MK 677 reviews.

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Now let’s take a look at two before and after photos so you can have an idea of what to expect from your MK 677 cycle. We gathered these two results from social media.

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This is an example of Ibutamoren only cycle. The results here aren’t that impressive, he could have definitely gotten better results by training harder and taking his diet a bit more serious. Still, it’s a nice little transformation without that much hard work

Just MK 677

His cycle:

WeekMK 677
1-1615mg a day

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We can see that this is a great and complete body transformation. The important thing to note here is that this person used LGD 4033 along with MK 677. This allowed him to gain a lot of muscle mass as well as lose some body fat.

An interesting thing about his cycle is that he didn’t use a PCT (Post Cycle Therapy) even though he used LGD 4033. This is because MK 677 by itself acted as kind of a PCT and he used a low dosage of LGD 4033 so he definitely didn’t even need to do it. You can read our article about PCT for LGD 4033 if you are interested in more information about this.

MK 677 + LGD 4033

His cycle:

WeekMK 677LGD 4033PCT
1-815mg a day5mg a day/
8-1615mg a day//

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I have done multiple Ibutamoren cycles and I plan to do more. Actually I do two 16-week MK 677 cycles every year.

From the compound, I experience an amazing increase in sleep quality. When I sleep for 6 hours, it feels like I slept for 8 and I’m completely rested. Another thing that I love about this compound is the hair and skin quality increase. My hair grows very fast and gets thicker during the cycle. I would even go as far as to say that my hair is thicker every since I have been doing two MK 677 cycles per year.

When it comes to muscle gains and fat loss, Ibutamoren is definitely useful. It’s not as good at it as SARMs, but it’s still noticeable. I think that gaining about 3-5lbs of muscle and losing a few lbs of fat is a good expectation from this compound. At the end of the day though, the results depend on your training and diet.

If you want to read a more in-depth review of this compound as well as other people’s opinions, read our article about MK 677 reviews.

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A lot of people are interested in MK 677 because they want to increase their height.

In short, yes, you can grow taller with this compound. The trick, however, is that your growth plates must be open.

So basically, if you are over the age of 25, for example, your growth plates are almost 100% closed and because of that you sadly won’t be able to grow taller with the help of Ibutamoren.

If you want more information on this topic, read our article on MK 677 height growth.

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Like we already mentioned, it’s very important that we buy high-quality, pure MK 677 to get the best possible results and to avoid unnecessary side effects. This is because some companies actually sell bunk products and because of that their effectiveness is a lot lower and they have a lot more side effects than a pure product.

I tested a lot of companies that sell Ibutamoren. The company that I recommend is hands down the best, it brings me the best results and I don’t experience any side effects with their products.

A good thing about them is that they are 3rd party tested for purity and that they have a 90day money-back guarantee. So basically you have nothing to lose and you don’t have to be afraid of getting bunk products and wasting your money.Recommended company for pure MK 677


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In conclusion, MK 677 is a growth hormone secretagogue that increases our natural production of GH (growth hormone) and IGF-1 (growth factor). It has a lot of benefits like increased muscle mass, fat loss, increased sleep quality and more. The great part is that this compound doesn’t have any serious side effects and it’s backed with a lot of research and studies.

My opinion on Ibutamoren is that it’s a great compound. I will continue to do cycles of this compound, I love the increased sleep benefit as well as the hair and skin quality increase. I recommend everyone to try this compound out, especially because it’s very safe and is backed by a lot of research.

We recommend that you buy high-quality MK 677 to get the best possible results and to avoid side effects from bunk products.

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This is the ultimate guide and review of Cardarine, also known as GW 50156 or Endurobol.

You will find this article very useful if you have questions similar to these:

  • What is Cardarine and how does it work
  • Does Cardarine actually work
  • Is Cardarine legal
  • Can Cardarine cause cancer
  • What are the benefits and the side effects of Cardarine
  • Where to buy high-quality Cardarine

We will answer all of these questions about GW 50156 as well as cover other topics such as the best dosage, example cycles and my experience with this compound.

Cardarine review

Keep in mind that Cardarine is considered to be a research compound and is not approved for human consumption. Don’t take the information you find here as medical advice, you should always talk to your doctor.

If you are in a rush and don’t have time to go over this article, check out this video. It’s not as in-depth but it goes over the important things about Cardarine.

Let’s start off by explaining what Cardarine actually is and how it works.

Table of Contents

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Cardarine is frequently mistaken to be a SARM (Selective Androgen Receptor Modulator). This is absolutely not the case.

Cardarine molecule
The GW 50156 molecule

In reality, GW 50156 is actually a PPARδ receptor agonist (Peroxisome proliferator-activated receptor delta agonist) and not a SARM at all.

It provides benefits like:

  • Increased endurance
  • Improved cardiovascular health
  • Fat loss

We will go over all the benefits of Cardarine in more detail later in the article.

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GW 50156 was designed in the 90s by Ligand Pharmaceuticals and GlaxoSmithKline to treat diseases like diabetes and cardiovascular diseases. If the name Ligand Pharmaceuticals sounds familiar to you, that’s because they developed and named LGD 4033.

Ligand pharmaceuticals

Cardarine went through a lot of studies and trials but the compound was ultimately abandoned in 2007 when a study was done by GlaxoSmithKline that showed cancer development in rats. More on this later.

After that, a lot of people discussed this and even some studies were done that have contradictive results (we will talk more about that later in the article).

Even though Cardarine got abandoned because of safety concerns, athletes, bodybuilders, and others started using it because of the amazing endurance benefits and fat loss it provides. Some people also use it to improve their cardiovascular health.

Shortly after people started using this compound, the WADA ( World Anti Doping Agency) added Cardarine and other PPARδ receptor agonists to the banned substances list.

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As we said, Cardarine is a PPARδ receptor agonist. This means that it binds to the PPARδ receptor to trigger some biological responses.

The main results of Cardarine binding to the PPARδ receptor are:

  • Increased oxidative capacity in muscles (This means more fat loss and a great increase in endurance)
  • Switching our energy source from glucose to fat (suppression of Glucose metabolism)

Scientists and athletes are most interested in the Glucose metabolism suppression effect that Cardarine has. Athletes love this because it’s one of the main reasons for the incredible endurance increase benefit that Cardarine provides.

science.bio cardarine

Scientists on the other hand, are very interested in this because it results in an increase in insulin sensitivy. This means that Cardarine has the potential to treat Diabetes.

Glucose metabolism suppression essentially means that the body starts using fat as an energy source instead of fat. Because of this, a lot of people started using Cardarine to help them lose body fat easier.

We will go over each benefit as well as the side effects and explain them in detail later in the article.

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Let’s clear this up right away, as of April 2020, Cardarine is legal to buy and use in every country in the world except for Australia. We will go over the legality in Australia later in the article. It’s also a little different in professional sports, we will go over that as well.

GW 50156 is sold under the labels of “Research Chemical” or “Not for human consumption” because it’s not FDA (Food and Drug Administration) approved for human consumption. This, however, doesn’t have anything to do with Cardarine being legal or illegal.

To summarize, Cardarine (GW 50156) is legal to buy and use in every country in the world with the exception of Australia. Now, let’s go over the legality of Cardarine in Australia.

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As we said, when it comes to the legality of Cardarine, Australia’s laws are a little different from the rest of the world.

sarms-australia

In Australia, Cardarine is considered to be a Schedule 9 compound by the TGA. This means that it’s illegal in Australia even with a doctor’s prescription. Fun fact, Cocaine is also considered a Schedule 9 drug in Australia.

SARMs and MK 677, however are legal in Australia with a doctor’s prescription.

Even though Cardarine isn’t legal in Australia, a lot of Australians frequently use it.

You can read more about this in my article on SARMs in Australia.

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Cardarine (GW 50156) is considered a prohibited substance for professional athletes by almost all sports bodies, including the Olympics because of the obvious unfair advantages that it gives (endurance increase).

sports doping

GW 50156 is on the list of banned compounds by the USADA (the United States Anti Doping Agency) as well as the WADA (World Anti Doping Agency) and the ASADA (the Australian Anti-Doping Agency).


If you want to read more about this subject, read our article where we answer the question; is Cardarine legal.

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As we said, GW 50156 has great benefits of fat loss, increased energy, an incredible increase in endurance, improved cardiovascular health and more.

Full list of Cardarine benefits:

  • increased endurance
  • fat loss
  • improved cardiovascular health
  • improved kidney and liver health

Now let’s go over each benefit in more detail.

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As we said earlier in the article, Cardarine actually increases our endurance in two different ways:

  1. Suppression of Glucose metabolism (switching energy source from glucose to fat).
  2. Increased oxidative capacity in muscles.

Both of these together result in a serious increase in endurance. Most people are able to increase their endurance by up to 60% after about 30 minutes from their first Cardarine dosage. Insane, right?

Rat studies actually proved this benefit. The studies showed that the group of rats that were taking Cardarine almost instantly had 50-70% more endurance than the other rats. In other words, it took them almost twice as long to get tired.

Cardarine endurance

So it’s not a surprise that a lot of athletes take GW 50156 just because of this benefit. Sadly, a lot of professional athletes use it as well to get an edge over their competition. In fact, Lance Armstrong is said to have used Cardarine as well as Stenabolic (a similar compound that increases endurance) to be able to win Tour de France 7 times.

You can expect to see increased endurance 30 minutes after your first dosage. You will get even better endurance week after week if you run and train hard. And the best thing about this is, you can keep most of the endurance you gained during your Cardarine cycle if you continue to train and run after the cycle is over.

Most people instantly see around a 50 – 60% endurance increase. This means that if you are able to run 2 miles, you will easily be able to run 3 miles after the first dosage. A lot of people even say that being on GW 50156 feels like you have three lungs because you can breathe so easily.

You won’t notice it only when running, you will also see the increased endurance when lifting weights. You won’t need as much rest time between sets, you won’t be out of breath as much, etc.

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Most likely, you are interested in Cardarine (GW 50156) just because of the fat loss benefit.

Similar to increasing endurance, Cardarine provides us with the benefit of fat loss in two different ways:

  1. Increased oxidative capacity in muscles – This means that we will burn more calories when exercising than we normally would without Cardarine.
  2. Suppression of Glucose metabolism – switching energy source from Glucose to fat. – This one is pretty self-explanatory. By switching the energy source from glucose to fat, we are able to directly burn off fat instead of first burning off the excess glucose that our body stored. In fact, the effect is very similar to a very strict ketogenic diet, but without actually doing the diet.

Lot’s of animal testings done on rats proved Cardarine helps a lot when it comes to fat loss. The studies showed that the rats that were on GW 50156 dropped 5% body fat more than the rats that weren’t taking the compound.

Cardarine fat loss

According to a study that tested Cardarine on 13 obese men with high body fat percentage and an unhealthy lipid profile. Just 2.5mg of Cardarine reduced their LDL, triglycerides and fatty acids.

In my experience, most people are able to drop 5-7% of their body fat over the course of an 8-week Cardarine cycle. You will be able to lose fat even when on a calorie maintenance diet or a slight calorie surplus. However, for the best results, I recommend that you stick to a slight calorie deficit diet during your GW 50156 cycle.

Remember, when it comes to fat loss, your diet and training will make the biggest impact. You can take as much of Cardarine as you want, if you have a bad diet, it won’t make much of a difference.

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This is actually one of the main reasons Cardarine was researched and developed, to treat cardiovascular diseases.

Studies and animal testings on rats showed that GW 50156 has a very positive effect on our cardiovascular system. It reduced the damage done to rats, improved their blood vessels and reduced inflammation.

cardiovascular health cardarine

Even low doses of Cardarine were shown to clear up blood vessels which lowers the risk of heart attack and other cardiovascular diseases. GW 50156 was shown to be effective at removing the plaque build-up in blood vessels.

In fact, some steroid users who take very strong steroids that are hard on your cardiovascular system, like Trenbolone, often take Cardarine so that they can avoid damaging their cardiovascular system and can stay healthy.

I will most likely use small dosages of Cardarine when I get older (over 50 years old) because of this benefit. It will allow me to have a very healthy cardiovascular system.My recommended companies for buying Cardarine

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Not a lot of people know this, Cardarine has a very positive effect on our liver and kidneys. This is really amazing because most similar compounds are actually liver or kidney toxic.

For kidneys, Cardarine showed that it reduces inflammation and studies found out that it lowers the chances of developing kidney disease.

GW 50156 liver and kidneys

GW 50156 also reduced the inflammation in the liver. It also switches the energy source from glucose to fat which is shown to improve our insulin resistance and this is beneficial for our liver and is obviously very beneficial to people who are struggling with Diabetes.

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Now that we have gone over the benefits of GW 50156, let’s take a look at the side effects.

Cardarine went through a lot of studies and research. So far, only one side effect was revealed and that is:

  • Accelerated development of cancerous tumors

The 2007 GSK (GlaxoSmithKline) conducted a study that showed an accelerated cancerours tumor development in rats that were taking Cardarine.

Some people are very skeptical of this study because they used absurd dosages of Cardarine for extremely long cycle periods. Since 2007, there have also been a lot of studies that are contradictory to the one that showed cancer development. Basically, the whole thing is a bit controversial.

Let’s go over this in-depth and explain when you should and when you shouldn’t worry about this.

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The thought of Cardarine accelerating the development of cancerous tumors is the reason why a lot of people aren’t using it even though it might be great for them. But are we really in the risk of developing cancer if we cycle GW 50156?

As of 2020, there have been 0 cases of documented cancer in people linked to Cardarine. Still, you need to be carefu and know everything about this compounds correlation to cancer. Let’s dive right in.

When it comes to the topic of Cardarine causing cancer, we have a lot of studies to look at.

cardarine cancer

On one side, we have the study that most of you already know. It was responsible for the discontinuation of Cardarine in 2007. Basically, it showed that the rats who were given Cardarine experienced fast development of cancerous tumors.

On the other side, we have a bunch of newer studies that proved that Cardarine doesn’t cause cancer at normal dosages for normal cycle length. In fact, the studies proved that at normal dosages, Cardarine has anti-cancer properties.

These studies are:

  • 2018 study
  • 2008 study
  • 2016 study

To better explain this, let’s first go over cycle length and the dosages that the rats were given in the 2007 study.

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A lot of people and a ton of websites claim that the rats were given a huge amount of Cardarine. Some of them are just listing random numbers like 50x, 70x, or even 100x the recommended dosage. But what dosages did they actually get?

The lowest dosage at which neoplastic was found in rats (neoplastic is just another word for tumors or cancerous tumors) was at 3mg a day.

Now let’s turn this 3mg a day dosage in rats to a human equivalent dosage (HED). We will use the human equivalent dose calculation based on body surface area from ResearchGate (picture below).

human dosage calculation

Human Equivalent Dose(mg/kg) = Animal Dose(mg/kg) x [Animal Km / Human Km]

= 3 x (6/37)

= 0.48 mg/kg

Where Animal Km is 6 for rats, and 37 for humans, and 3mg is the lowest dose where neoplastic findings were found.

For a 190 pound / 85 kg person, this is the equivalent of 40.8mg per day. Or 43.2mg per day for a 90kg person.

So as you can see, the dosages used were about 4x bigger than the recommended dosages, not 100x or 50x as some people claim.

Another important thing is the cycle length used in the study. The study ran for 104 weeks, which is about 13x more than the maximum recommended cycle length of 8 weeks.

To summarize, the dosages used in the infamous rat study were 3x higher than recommended and the length of the study was 13x longer than the recommended cycle length.

Keep in mind that it took all of this, 3x higher dosages, and an absurd cycle length for cancer to show up.

If you take normal dosages and stick to normal cycle length, you will almost certainly be fine. Some recent studies even confirm this, let’s look into them.

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This GW 50156 study proved that Cardarine doesn’t cause cancer at high dosages and short cycle lengths.

I recommend that you read the study for yourself if you are interested, it’s very long and in-depth. If you don’t have the time, however, let me summarize it for you.

Neither GW compound increased cell growth or phosphorylation of Akt and no increase in the expression of VEGF or COX2 were detected in any cancer cell line in the presence or absence of serum. Similarly, liver, colon and colon polyps from mice administered these compounds did not exhibit changes in these markers.

https://www.evolutionary.org/wp-content/uploads/2014/07/PPAR-does-NOT-cause-cancer.pdf

Essentially, this study proved that Cardarine doesn’t cause the development of cancerous tumors even at high dosages for normal periods of time. Not only that, the compound was shown to actually have some anti-cancer properties in this period.

They used dosages comparable to taking 154mg a day as a 90kg person. These high dosages didn’t show any signs of cancer development at cycle lengths of 7 days.

Basically, this means that high dosages for normal periods of time won’t cause cancer and we could assume that the reason cancer occurred in the 2007 rat study was because of the absurd cycle length (104 weeks), not the high dosages or maybe a combination of the two.

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Let’s summarize the topic of GW 50156 causing cancer.

Yes, Cardarine can cause cancer, but only if taken at high dosages (over 40 mg a day) for a very long period of time (104 weeks in the case of 40mg a day). Obviously, a 100mg a day dosage could cause cancer sooner, at 50 weeks.

If you take Cardarine correctly and stick to normal cycle lengths and dosages, you wont have any problems. In fact, a study actually proved that GW 50156 actually has anti-cancer properties if taken accordingly.

This redditor also adds a very nice point to all of this:

redditor on cardarine causing cancer

As of 2020, there have been no documented cases of cancer in humans linked to Cardarine. I assume that this is the case because nobody is taking it for 104 weeks straight at 40mg a day.

Make sure to follow these two rules to be safe:

  • Normal cycle length (maximum of 8 weeks)
  • Normal dosages (maximum of 15-20mg a day)

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Contrary to popular belief, there have been many GW 50156 human trials done and no, none of them got cancer.

There were three Cardarine human trials:

  • First study, 2007
  • Second study, 2011
  • Thrid study, 2012

These human trials showed that Cardarine isn’t liver toxic as there were no changes in the liver that could demonstrate damage.

Also, there were significant, very positive, changes to HDL, cholesterol, and triglycerides. The second and third studies also saw improvements in insulin sensitivity and a decline in fatty acid ~20%.

Not only that, but these human trials also saw a big improvement in body composition. However, body fat% data wasn’t captured so there is no clear data on that.

An interesting thing about these human trials is that some groups were given dosages of 10mg a day for 12 weeks. These dosages gave all of the mentioned benefits and didn’t show any side effects.

Because of this, a lot of people, including me, take Cardarine at 10-15mg a day for 8-week cycles without worrying.

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I have taken multiple cycles of Cardarine of 15mg a day for 8-weeks. I really like this compound especially because it has literally no side effects if you take it this way, two studies confirmed that it won’t cause anything to do with cancer for periods and dosages like this.

The last time that I took it, I stacked it with a small dosage of 10mg a day of Ostarine. This let me to easily get rid of all my fat and keep all my muscle mass (even gain some). It easily leaned me out, I lost my fat and dropped to about 9% body fat from 15 or 16% body fat. Keep in mind, I was careful with my diet and training as well.

Overall, this is a great compound in my eyes. I absolutely love the endurance benefit, it makes cardio easy for me. Not to mention all of the healing properties of Cardarine for the liver, kidneys and heart. I would say it’s very similar to Stenabolic but I feel like it is more effective at fat loss and endurance gain.

My cycle:

WeekCardarineOstarine
1-815mg a day10mg a day

If you want to read my in-depth review, read my article about Cardarine results.

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As we said, Cardarine isn’t a SARM. It is also non-hormonal and won’t cause us to have a suppressed natural production of Testosterone.

This means that we don’t need a PCT (Post Cycle Therapy) for Cardarine. PCT is actually a very serious thing and can have serious side effects. This is why we shouldn’t do a PCT if we don’t need to. You definitely need a PCT with steroids but with SARMs that’s not the case.

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Now that we’ve covered my experience with this compound, let’s go over some real Cardarine reviews and results from other people.

We will go over the results from two people, if you want to read more reviews from other people, read our article about Cardarine before and after. There we go over more before and after pics and their Cardarine cycles.

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Cardarine results

His cycle:

WeekCardarine
1-820mg a day

This is a good example of what you can expect to see from your Cardarine cycle. He (the person in the photo) lost about 5% body fat and managed to keep most of his muscle mass.

Train at least 3-4 times a day as well as have a moderately clean diet and you will easily be able to achieve results like this using the same cycle as he did.

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Cardarine before and after

His cycle:

WeekCardarineOstarine
1-815mg a day10mg a day

As we can see, this is an example of a Cardarine – Ostarine cycle. He achieved decent results, nothing spectacular though. You should easily be able to achieve and surpass results like this with a decent diet and hard training. The person in the photo lost a few % of body fat and probably gained about two lbs of muscle mass.

You should be able to achieve results like this even without the help of Ostarine

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Cardarine is non-hormonal, it won’t cause any suppressed production of natural Testosterone. This means that we can easily stack it with any SARM without problems or complications.

We actually recommend that you stack it with SARMs like Ostarine or LGD-4033, depending on what you are trying to achieve. If you want to put on lean muscle mass and no fat, we recommend LGD-4033 and if you want to cut and keep all your muscle mass you should stack it with Ostarine.

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We will go over two Cardarine cycles. Cutting cycle and bulking cycle. Both of these examples are using SARMs with GW 50156. Keep in mind that if you want, you can cycle only GW 50156 as well.

Cutting cycle:

This is a great cutting cycle, it will let you keep all your muscle and put on some as well. You will easily lose your fat and be full of energy. Don’t forget that diet and training will be very important, we can’t avoid that. We won’t need a PCT for this cycle. Ostarine is really mildly suppressive, our body will easily recover naturally in a few weeks after the cycle.

The cycle:

WeekCardarineOstarinePCT
1-815mg a day10-15mg a day/

Lean bulk cycle:

This example is a great lean bulking cycle. We will gain only lean muscle and lose some fat at the same time as well. Keep in mind, training and diet will be very important, we won’t be able to avoid that. We also won’t need a PCT for this cycle. The LGD-4033 dosage isn’t high enough to cause problems and our bodies will easily be able to recover naturally after the cycle.

The cycle:

WeekCardarineLGD-4033PCT
1-815mg a day2.5-10mg a day/

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We recommend that you run a dosage of 10-25mg of Cardarine a day to see the best results. Beginners should obviously start at 10mg and work their way up. Dosages like were also shown to have no signs of risk of cancer so this is why we recommend that you stay in this range.

You should cycle Cardarine for 8-weeks. Some people do 12-weeks without problems but we still recommend 8 because a study that we mentioned earlier showed that this cycle length is safe and has no side effects.

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GW 50156 has a half-life of 24 hours. This means that in order to keep the optimal levels of Cardarine in our body (to get the best possible results), we should take a dosage once every 24 hours. If you forget a dosage, don’t worry, just take the normal dosage (not a double) the next day and continue your cycle normally.

cardarine half-life

Some recent studies have shown, however, that the half-life of Cardarine might be somewhere between 10-24 hours.

So that is why you can even take it a step further by splitting your dosage into two parts. Studies have shown that this is actually superior to taking one dosage a day. Although the difference is not that big, it’s still worth trying.

Take the first part in the morning and the second part in the evening. So for example, if you are taking 20mg of GW 50156 a day, take the first 10mg in the morning and the second 10mg in the evening.

You can read more about this in our article about Cardarine half-life where we answer the questions like; the best time to take GW 50156, etc.

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A lot of people aren’t sure how fast Cardarine actually kicks in. It’s important that we know this so that we can easily tell if our Cardarine is bunk or not.

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When it comes to the increased endurance, Cardarine starts working in about 20 minutes after the first dosage and lasts throughout the whole cycle. Usually, the endurance starts gradually going down after the cycle, but if you do a lot of cardio even after the cycle, you can manage to keep most of the endurance.

Increased endurance is also a very easy way to tell if your GW 50156 is real. If you don’t get an increased endurance after the first dosage, try increasing your dosage. But if you still don’t get an increase in endurance even when you try 25mg a day, for example, you almost certainly have a bunk product.

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The increased cardiovascular health also comes in very fast, in the first two weeks. Obviously, we can’t see this without doing a blood test, but it’s still good to know that our cardiovascular health will improve fast.

Some people who are using compounds that give our cardiovascular system a hard time (trenbolone, for example), love to use Cardarine because it makes it safe. They say that according to their blood tests, GW 50156 makes a huge positive difference in blood pressure, cholesterol levels, etc. in only a week.

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Most people, however, are interested in the fat loss benefit. That takes a little bit longer to kick in compared to the endurance or the increased cardiovascular health. In my personal experience, you can expect to see the first signs of fat loss in the first two to three weeks of the cycle. Obviously, if you train hard and keep an eye on your diet, you will notice it faster.

On average, though, if you eat at calorie maintenance and train decently often, you will see fat loss progress by the end of the second or third week.

Tip: Take frequent photos of yourself, this way you will have an easy time tracking your progress.

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Obviously, if you want good results and no side effects from a compound like Cardarine, you have to make sure that you have high-quality, pure compounds. Some companies sell products like SARMs and GW 50156 but actually put very little of the actual compound into their products and put something else in there instead, like prohormones. This can obviously have serious side effects and won’t bring you the results you want.

This is why it’s so crucial that you buy your GW 50156 and other compounds from trusted companies that don’t sell bunk products.

I recommend that you buy your Cardarine from my recommended company. I tested their Cardarine and I can guarantee that it is pure and high-quality. You will experience incredible benefits from their compounds and won’t experience any side effects.

Plus, they have a 90-day money-back guarantee if you aren’t satisfied with the products, so you have nothing to lose.My recommended companies for buying Cardarine

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In conclusion, Cardarine is a great product that has incredible benefits like:

  • endurance
  • fat loss
  • improved cardiovascular health
  • improved kidney and liver health

A lot of people are scared off because people talk about cancer when they talk about GW 50156. In reality, this compound won’t cause cancer at normal dosages at all. Recent studies have shown that the infamous Cardarine rats most likely got cancer because of the absurd cycle length (2 years).

Also, Cardarine is amazing when we stack it with compounds like Ostarine or LGD-4033. We can cut and keep all our muscles or bulk without putting on any fat. But don’t forget, these compounds aren’t magical pills that will let us do whatever, training and diet will still be very important and the most important factor for our results.

Don’t forget that you should always buy your compounds from trusted sellers like my recommended companies, this way you can be sure of what you are getting.

Cardarine rating based on my opinion: Cardarine rating9.2/10

FAQ About Cardarine – GW 50156

Let’s go over some FAQ (Frequently Asked Questions) about Cardarine ( GW 50156) and answer them.

What Is Cardarine (GW 50156)?

Cardarine is a PPARδ receptor agonist that has benefits like improved endurance, cardiovascular health, fat loss as well as improved kidney and liver health.

How Does Cardarine (GW 50156) Work?

Cardarine will switch our energy source from glucose to fat. This means that we will burn off more fat and we will have more endurance.

What Is The Proper Cardarine Dosage?

The proper Cardarine dosage is between 10-25mg a day. Beginners should start at 10mg a day.

What Is Cardarine Half-Life?

The half-life of Cardarine is 24 hours. This means that we should take one dosage every 24 hours for the best results.

What Side Effects Does Cardarine Have?

A study found that Cardarine can cause the development of cancer. Keep in mind, the study used 50x the recommended dosage for 2 years straight.

Is Cardarine Legal

As of 2020, you can legally buy and use Cardarine in every country in the world except for Australia. In Australia, it’s considered as a Schedule 9 compound by the TGA which means that it’s illegal even with a doctor’s prescription.

Does Cardarine Actually Work

Yes, Cardarine absoluletly works. In fact, it’s so effective that people feel it as soon as 20 minutes after the first dosage.

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SR 9009

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SR9009, also known as Stenabolic, is a synthetic drug created to study the circadian rhythm. It was shown to boost endurance, reduce anxiety, and decrease cholesterol, weight, and inflammation in mice. These effects, if proven in humans, would replicate some of the beneficial effects exercise has on our bodies. However, Stenabolic has not been tested in humans at all! Its side effects are also unknown. Read on to learn why it’s dangerous.

Disclaimer: We highly recommend against using this drug since its effects and safety are completely unknown. No human data on it have been published so far. Therefore, we are presenting the available information from the scientific literature with the aim of helping readers understand the dangers involved.

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Stenabolic or SR9009 is a research chemical. To date, no human studies on the use of SR9009 have been published. 

Thus, we don’t know how dangerous this substance may be. Its effectiveness in humans is also unknown. This means it has a high potential for harm and should be avoided at all costs.

Our bodies function in a coordinated manner, in 24-hour cycles that are adjusted to the rise and fall of the sun. This pattern is called the circadian rhythm.

The circadian rhythm is maintained through a loop mechanism that turns genes on and off (when CLOCK and BMAL1 genes are turned on, they turn on PER and CRY. Then, PER/CRY turn BMAL1/CLOCK off and the 24-hour cycle resets) [1].

The REV-ERBs are a pair of proteins that stabilize our internal clock by turning BMAL1 off. They are, in turn, activated by the heme group. Heme is a small iron-containing compound found all throughout our body, for example, in red blood cells [1, 2].

SR9009 is a compound that enhances REV-ERB activity (known as agonists) and has good bioavailability [3].

Because of the many positive effects seen in animals, SR9009 found its way online and is being sold and used as a supplement, mainly within the bodybuilding community. It has been referred to as “exercise in a bottle.” However, there are still a lot of things we don’t know about this drug, including its side effects.

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All the effects observed for SR9009 derive from REV-ERB (NR1D1, NR1D2) activation in the body.

REV-ERB affects the circadian behavior of mice, altering their activity and sleep patterns [4].

Besides its effect on the circadian rhythm (suppression of BMAL1 production), REV-ERB affects many other functions related to energy production [4, 5].

REV-ERB is mainly found in liver, muscle, and fat tissue:

  • Liver: REV-ERB affects the rhythm of 90% of the about 900 genes under circadian control in mice liver. It turns off the genes that produce glucose without altering insulin sensitivity. It also turns on genes that generate new fat cells and reduces the inflammatory response (by affecting macrophage production) [4, 6, 7, 2].
  • Muscles: REV-ERB promotes the burning of fat, increases the activity of mitochondria, and promotes the generation of new while decreasing the destruction of old mitochondria [5].
  • Fat cells: REV-ERB turns off the genes responsible for storing fat and decreases triglyceride production [8].

In animal and cell studies, SR9009:

  • Increased oxygen consumption [8]
  • Decreased generation of new fat cells in the liver [8]
  • Decreased production of cholesterol and bile acids in the liver [8]
  • Increased the number of mitochondria in muscle [5]
  • Increased glucose and fatty acid use in muscle [8]
  • Decreased fat storage [8]

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Mice injected with SR9009 for 7 days lost weight due to a decrease in fat mass. Food intake was not affected [8].

Similarly, diet-induced obese mice injected with SR9009 for 30 days lost 60% more weight than control animals. Blood levels of triglycerides, total cholesterol, free fatty acids, and insulin levels also decreased [8].

In genetically obese mice, SR9009 stopped weight gain after 12 days without affecting glucose levels or insulin tolerance [8].

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SR9009 given for 7 to 10 days reduced blood levels of triglycerides and total cholesterol in mice [8].

Genetically modified mice undergoing a high cholesterol diet to obtain a fat profile similar to humans were given SR9009 for 8 weeks. Total cholesterol and triglycerides were similarly lowered, while LDL cholesterol was lowered but HDL cholesterol was unaffected [9].

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Mice treated with SR9009 for 30 days showed increased endurance. They ran for a longer time and covered more distance than controls [5].

SR9009 increased the number of total and active mitochondria in muscle cells (by repressing autophagy genes) [5].Help Protect Yourself From Coronavirus by Optimizing Your Health!

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SR9009 diminished lung inflammation in rats (by reducing the production of TNF-alpha) [10].

It also reduced the production of inflammatory molecules (CCL2, MMP-9) in rat nerve cells [11].

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Genetically modified mice susceptible to hardening of the arteries were treated with SR9009 for 7 weeks. The size of the blood vessel lesions was reduced, while food intake, body weight, and blood fat levels were not affected [12].

In both normal and genetically modified old mice, SR9009 injected for 28 days improved heart function [13].

In mice with surgically induced heart growth (hypertrophy), SR9009 given for 2 weeks reduced heart size and weight, with no effect on blood pressure [13].

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As an activator of REV-ERB, S9009 changes sleep/wake patterns in mice. However, its effects are short-term and last only 12 hours [14, 15].

Mice injected with SR9009 during daytime (this is when the mice are supposed to be asleep) were more active during the day and had less deep sleep (less REM and slow-wave sleep). However, when SR9009 was injected during the night (when mice are active), it had no effect [14, 15].

SR9009 may potentially help in maintaining wakefulness when the drive for sleep is significant including shift work, jet lag, and some sleep-related disorders.

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SR9009 injected twice a day for 3 to 10 days, decreased anxiety-like behavior in mice and was as effective as a benzodiazepine [14].

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SR9009 decreased tissue damage in mice with induced liver scarring when treated with SR9009 for 2 weeks [16].

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The side effects of SR9009 are unknown. This drug has serious potential for harm. Taking would be extremely dangerous since its safety profile has not been investigated.

So far, SR9009 has shown no liver toxicity in mice when used for up to 7 weeks [12].

Some users reported insomnia.

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No human dosage has been established so far. Most experiments in mice have used a dose of 100 mg/kg applied intraperitoneally; that is, injected directly into the body cavity.

Online bodybuilding forums, however, suggest a much lower daily dose of 10-40 mg. They also suggest dividing this into 3-4 doses per day.

There are no scientific reports on the effectiveness of SR9009 when taken orally.

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To date, no scientific studies on the use of SR9009 in humans have been published.

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SR9009 is sold online for use as a performance enhancer in bodybuilding.

Some users report improved endurance, while others state it has limited or no benefits. For many, the suggested repeated dosing (3-4 times a day) makes it bothersome to use.

  • “I feel it immediately. With SR9009 it’s like there’s this little “pop” of alertness. It can cause insomnia (which happened to me), and might explain that “pop” like a flash of “it’s daytime!”
  • “I’ve used it a bit. The energy and stamina increases are pretty pronounced.”
  • “It gives really nice increases to endurance, but feels different than a traditional stimulant.”
  • “Didn’t feel much.”

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There are vendors who sell SR9009 in the United States.

We at SelfDecode advise speaking to a doctor before taking any drug, especially an unscheduled drug with limited long-term safety data in humans.

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Ostarine, also known as Enobosarm, is an unapproved drug. Despite the hype among some bodybuilders, Ostarine never passed clinical trials. Learn about its uses, side effects & dangers.

Disclaimer: We highly recommend against using this drug since its effects and safety are unknown. Therefore, we are presenting the available information from the clinical and scientific literature with the aim of helping readers understand the dangers involved.

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Ostarine (MK-2866), also known as enobosarm, is a selective androgen receptor modulator (SARM). SARMs like Ostarine stimulate steroid hormone receptors – androgen receptors – mimicking testosterone [1].

Scientists initially hypothesized that, unlike typical steroids, SARMs would be able to target specific tissues, such as the muscles or bones. In theory, this was supposed to limit their side effects [1].

Bodybuilders tend to take this unapproved theory as “proof” that they won’t have to deal with severe testosterone suppression and increased estrogens if they take SARMs. However, this is far from true.

Still, SARMs have surfaced as a popular new class of appearance and performance enhancers. People misperceive them as safer and “cleaner” due to a basic misunderstanding of the available scientific data, which is hyped in various bodybuilding blogs.

Many bodybuilders and athletes swear by Ostarine and claim it offers significant muscle mass and performance gains with few risks.

In reality, the “SARMs selectivity theory” might be completely false. It has never been proven, and SARMs like Ostarine never passed proper clinical trials. SARMs may turn out to be much more dangerous than previously thought.

To create further confusion, some researchers believe Ostarine might be safer than steroids, though they still have no data to back up their claims. Additionally, it has not yet been approved for human use anywhere in the world [2, 3].

Ostarine is being researched for its ability to improve serious muscle wasting diseases. Interestingly enough, it is one of the few SARMs still in clinical trials while most others proved to be toxic. It may be approved for clinical use if the trials attest to its favorable benefits/risks ratio [3].

However, its use in professional sports will almost certainly remain illegal. The World Anti-Doping Agency banned Ostarine under the S1 Anabolic Agent category of the Prohibited List, along with all other SARMs back in 2008.Ostarine is a selective androgen receptor modulator (SARM) touted to boost muscle mass. Although banned in professional sports, it’s still being medically researched.

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Proponents

  • Increases lean muscle mass and strength
  • Shouldn’t cause hormonal imbalance
  • May improve bone strength
  • May lower cholesterol and improve insulin resistance

Skeptics

  • No clinical data to back up proponents’ claims
  • Not allowed for use in professional sports
  • Not approved for human use
  • Effects and efficacy are unknown
  • Short- and long-term side effects have yet to be investigated
  • Long-term risks and safety are unknown
  • Drug interactions remain unexplored
  • Products sold online are not intended for human use
  • These products usually contain a mix of dangerous, unapproved drugs

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It’s no secret that androgens increase skeletal muscle mass – that’s the main reason why men typically have more muscles than women. The activity of androgens in the body goes well beyond muscle-building, though. When sensors for androgens are non-selectively stimulated by drugs like steroids, it usually results in a long list of side effects.

SARMs are hypothesized to target muscles and increase anabolic processes while sparing the reproductive organs. Among many synthesized SARMs, the structure of Ostarine seems to offer some potential “advantages.”

In one study on mice, Ostarine was as effective as the most influential androgen, dihydrotestosterone, at restoring the size of pelvic floor muscles. Muscles in the pelvic floor are especially rich in androgen receptors (AR) [4].

Ostarine could also activate muscle stem cells (satellite cells), which help remodel and regenerate muscles. Surprisingly, it turned out that Ostarine also stimulates cells in the connective tissue, which are important for a successful recovery from muscle injuries [4].

Ostarine increased the activity of the insulin-like growth factor 1 gene (IGF-1), which boosts muscle growth and strength [4, 5].

However, we can’t make any conclusions based on data from cellular studies. Many drugs show some “promise” at the cellular level, only to be abandoned due to a lack of efficacy or risk of toxicity in later animal or human studies.Although Ostarine is believed to target androgen receptors in muscles while sparing reproductive organs, no data backs this hypothesis up. Clinical studies are lacking.

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Ostarine is being researched for reversing muscle loss in cancer patients, people with muscular dystrophy, and the aging population.

In a clinical trial of 120 healthy elderly people, enobosarm increased lean muscle mass and fitness. Only those who received 3 mg of enobosarm daily for 12 weeks saw benefits, while lower doses did not work as well. Importantly, its side effects were similar to placebo, with no steroid-like risks [6].

In another trial, enobosarm increased lean muscle mass in 159 cancer patients. Cancer patients who already started to lose muscle mass prior to the study gained about 2 – 3 lbs after taking enobosarm for about 4 months. The lower (1 mg/day) and the higher (3 mg/day) dose worked equally well [7].

Large clinical trials of enobosarm for preventing muscle loss in cancer patients are currently underway [8].Ostarine may increase muscle mass and prevent muscle wasting in older people and cancer patients.

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A decrease in bone-protective sex hormones with age increases the risk of poor bone health and osteoporosis. Increasing muscle mass can reduce the risk of bone fractures and speed up recovery, especially in older people [9, 10].

Since Ostarine mimics testosterone in the muscles and bones, it has the potential to prevent bone diseases. Animal studies confirmed that SARMs like Ostarine could increase both muscle and bone strength. No human study has confirmed the benefits yet [9, 3].

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Ostarine may also be beneficial for people with heart disease, who often suffer from muscle wasting and weight loss [11].

In a clinical trial of 120 healthy elderly people, enobosarm (1-3 mg/day) lowered triglycerides, total cholesterol, and HDL cholesterol. Healthy lipid levels help prevent heart disease. However, lowering HDL is not typically considered beneficial [12].

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In the above-mentioned study, enobosarm improved insulin resistance and lowered blood glucose. The effects were similar to standard anti-diabetic drugs such as metformin. With more research, Ostarine may benefit people with diabetes or metabolic syndrome [12].According to limited and preliminary data, Ostarine may lower blood lipids and sugar and improve bone health. Far more research is needed to confirm these findings.

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Ostarine has good bioavailability. Rats completely absorbed Ostarine, transported it throughout the body, and eliminated it via feces mostly as an unchanged drug [13].

Dosage in clinical studies: 1-3 mg/day, up to 4 months [14, 6].

Ostarine and other SARMs are also being researched for breast cancer, incontinence, low testosterone in older men, and muscular dystrophy [3, 15].

There is no safe or effective Ostarine dosage since it has not passed proper clinical trials or received approval from any regulatory body.

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The official scientific research about Ostarine is highly limited. It was researched only in cancer patients and elderly people. None of the conducted studies to date have determined if Ostarine works and how dangerous it can be. Based on the existing data, its effects are unknown and its potential to cause harm is high.

Here we summarized the available reviews and feedback from online communities with the attempt to additionally warn people about the dangers of taking this unapproved drug.

Note: All the information below is anecdotal and based only on the personal experiences of Ostarine users. We can’t attest to its accuracy. We also can’t say to what extent these experiences are affected by other SARMs or different drugs/supplements taken at the same time. And lastly, we are far from sure about the actual content and quality of Ostarine in numerous products users bought online.

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The reported “benefits” of Ostarine appear exaggerated and overhyped across various bodybuilding forums. For example, cancer patients gained 2 – 3 lbs after taking 3 mg/day for 4 months in clinical trials, while bodybuilders report gaining 6 – 8 lbs from approximately 25 mg/day during bulking cycles.

Users that consider Ostarine a “clean drug,” saying it helps them “increase pure muscle mass and burn fat with minimal side effects,” usually promote various SARMs on their blogs. Most completely ignore the fact that Ostarine is an unapproved drug with completely unknown effects on the body.

Those who do use steroids take Ostarine as a PCT or in between cycles of steroids to maintain muscle gains. Others who stick to SARMs still take regular PCT after Ostarine cycles.

Additionally, users claim the results gained with Ostarine are easier to maintain. All in all, bodybuilders claim it offers gains in all phases – from bulking cycles and cutting to body recomposition and muscle recovery.

Women seem to prefer Ostarine as well, since it supposedly doesn’t cause male-like hair growth, deepening of the voice, or other signs of high androgens.Bodybuilders believe Ostarine will give them lasting pure muscle gains. Anecdotal information aside, we know neither how effective nor how safe Ostarine is.

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Users report:

  • Pure, clean, dry lean muscle gains (~6 – 8 lbs)
  • Milder gains than with steroids
  • Increased strength, stamina, and lifting endurance
  • No water retention
  • Great pumps during workouts
  • Increased energy and sense of well-being
  • No post-cycle crashes
  • No need for pre-cycle supplements
  • No need for liver-support supplements
  • No increases in aggression
  • Women report more obvious muscle gains and fat loss than men

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Users report the following effects of Ostarine for cutting cycles:

  • The Big One: maintaining muscle mass
  • No strength loss
  • Fat loss

For all bodybuilders, the major downside to cutting cycles is muscle loss. That’s probably why so many love Ostarine – they say it prevents muscle breakdown but helps burn fat. This is probably the most talked-about aspect of Ostarine for bodybuilding.

Going back to the basics, it’s impossible to avoid being in caloric deficit if you want to burn fat and lose weight. However, your body will always interpret caloric deficit as a signal to break down all available energy stored in the body, including the proteins in your muscles.

Users report that Ostarine stalls this catabolic process, apparently stopping the body from using proteins as fuel but still helping to burn fats. Users say it helped them maintain muscles despite being on a low-calorie diet, keeping the anabolic processes going. They sometimes combine it with Cardarine to boost cardio endurance.Ostarine is popular in bulking cycles but even more so in cutting cycles. Users say it stimulates fat burning and prevents muscle loss, but its actual effects and safety are unknown.

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Used for recomping, Ostarine users reported:

  • Gaining muscles
  • Losing fat
  • Gaining some weight overall (depending on the diet and total number of calories consumed per day)

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Users report:

  • Enhanced muscle recovery (at lower doses) after a week or two
  • Improved injury prevention
  • Better joint mobility
  • Healing of bone and tendon injuries

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One user explained how taking only Ostarine allowed him to maintain muscle gains after coming off TRT (testosterone replacement therapy). He didn’t lose any weight and even reported increased strength. A rebound effect after TRT is common and muscle loss is one of the most feared downsides.Bodybuilders report using Ostarine for recovery, body recomposition, and coming off TRT – but evidence supports none of these anecdotal uses.

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The dosing data in clinical trials is limited and Ostarine has not been approved for human use. This drug has no “safe” or “effective” dosage and holds serious potential for harm.

Despite these dangers, the Ostarine-community seems to have established unofficial dosage guidelines based on “trial and error.” Bulking doses (3 – 8 weeks):

  • Most male bodybuilders use 25 mg/day
  • Women typically use up to 10 mg/day

The number of people who have suffered serious adverse effects is unknown.

The dose favored by most men for bulking is almost 10 times greater than the dose used in cancer patients, which is highly troubling. Megadosing an unapproved, poorly-researched chemical can be extremely dangerous. Nobody knows what the consequences may be.

Since Ostarine has a long half-life (24 h), most people take the daily amount all in one shot. Some still split the daily dose into 2-3 chunks.

The same users report cutting doses (4 – 8 weeks) or for injury prevention:

  • Men: 15 – 20 mg/day
  • Women: not mentioned, but the men dose is usually halved

Body recomposition (4-8 weeks)

  • The dose ranges between 12.5 – 25 mg/day

Some users reported taking Ostarine alone (especially for bulking cycles) while others combine it with other SARMs and slightly lower its dose.

Stacking several unapproved drugs (e.g. Ostarine and other SARMs) together is a dangerous practice. It increases the potential for harm since the effects, side effects, and interactions of these drugs have not been investigated. The long-term risks are even less certain.Since Ostarine is an unapproved drug with unknown safety, it should not be taken at any dosage.

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Ostarine is commonly cycled for up to 12 weeks. Users who stopped cycles at the 8-week mark experienced fewer side effects. While some users don’t experience any side effects even with cycles lasting over 12 weeks, the chances undoubtedly increase.

As a general rule among experienced bodybuilders, time off should equal the duration of the cycle. As an example, this would mean taking a 12-week break from ostarine after cycling it for 12 weeks and using PCT for 3-4 weeks. The time off is usually counted after PCT.

Some think that the strict time on=time off rule should be abandoned for more personalized strategies. Proponents of shortening the time off recommend ordering detailed lab tests after the cycle + PCT to assess overall hormone levels and any potential problems.

If everything is alright, some restart Ostarine cycles soon after (1-week breaks). However, if the labs point to health problems, delaying Ostarine or any other bodybuilding supplements is a must for all sensible users.Ostarine is a dangerous drug. Speak with your doctor about safer alternatives.

We advise speaking to a doctor before taking any drug, especially an unscheduled drug with limited long-term safety data in humans.

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As mentioned, the World Anti-Doping Agency banned SARMs as they can increase physical fitness and stamina.

In limited studies, Ostarine was well tolerated and posed an insignificant risk of drug interactions with commonly used medication (antibiotics, antifungals, statins, and Celebrex). However, the existing studies did not focus on Ostarine’s side effect profile. Larger, better-designed studies are needed [16, 17].

Side effects from clinical studies include headaches and back pain. The long-term effects of Ostarine are unknown [18].

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The truth is that so little information is out there about the side effects of Ostarine. Being a banned substance with clinical research done only in cancer patients, the available scientific literature is extremely limited.

To get a better idea of what side effects people report, we decided to take a closer look at user reviews. Ostarine has been reported to raise blood estradiol and suppress testosterone.

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Developed by GTX Inc, Andarine S4 is a SARM whose functionality is similar to that of steroids but instead work selectively on the Androgenic Receptors. This way it helps you gain a lean muscle weight minus the worrisome side effects. In this article we shall talk about what Andarine does, its dosage, benefits, side effects and its legality in research, sports and as food supplement.

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Everyone wants to have a healthy body that looks fit. Bodybuilders and athletes work day in and day out in the gym to get that perfect shape. In addition to that, proper sleep and a proper diet is really important. But at some point, they start feeling exhausted or maybe they simply want to practice more.

For enhancing their performances in the gym or practice, previously people started using steroids but they come with too many negative side effects. Meanwhile, SARMs started gaining its popularity. This drug lets you have THE energy for longer hours and at the same time, taking them in a cycle helps you add lean muscle mass and burn the fat from your body making you look and feel strong.

Plus, they do not have any harmful side effects like those in steroids, which is also the main reason for its quick fame among the bodybuilders and athletes

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Andarine S4, also known as Acetamidoxolutamide or Androxolutamide or GTx-007 was created by a Japanese company Kaken Pharmaceuticals and later developed by GTX Inci. The main compound in the drug is antiandrogen bicalutamide. Andarine was introduced for curing muscle wasting, breast cancer, prostate cancer, benign prostatic hypertrophy and degenerative disorders like osteoporosis. Andarine S – 4 has shown to promote weight reduction of the prostate gland in people suffering from prostate cancer. It also greatly helps in increasing muscle mass. Plus, S4  helps to oxidize the fat in the body. This property was what made bodybuilders and athletes start using them as a safer alternative to Anabolic steroids. This is good for both cutting and bulking.

Andarine is much lesser potent than any other SARMs and it has a half-life of approximately 3 – 6 hours. It does not aromatize and thus prevents the excess release of estrogen and does not cause negative effects like high blood pressure or problems with the cardiovascular system. Andarine promotes the healing process in the case of fractured bones and cures the pain associated with brittle bones.Visit Official Website For More Information


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As mentioned earlier, Andarine S – 4 is a low potent drug compared to other SARMs, RAD 140 Testolone being the most potent one. So people often opt for higher dosages. We recommend lower doses so that the chances of having any unwanted effects gets minimal.

Dividing it into 3 separate doses that totally equal 25-30 mg per day is the most appropriate dosage is what our team found. You may need to use it only 5 days a week with 2 days gap between and this cycle goes on for 10-12 weeks. This dosage ensures you don’t get detrimental side effects like messing up with your eye vision. People taking a dose of 50 –75 mg/day will experience some unwanted effects like blurry vision and increased stress. That is why it is advised to take the drug only in doses in the lower levels.

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Andarine helps reduce the High Density Lipoproteins​ (HDL) and has the ability to repair bone fracture, promote bones and muscle development thereby preventing muscle loss. It also uses the fat in your body and helps burning extra fat, aiding in recupering. Having protein-rich food alongside the SARM dosage is really important since only then the drug works in its complete efficiency.

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When you start getting muscular, you want to make sure that your body does not look like it is just swollen. Removing excess water from your body is important here. Andarine does not aromatize, hence do not cause water retention and also burns down the fat in your body. These properties make your body look sharp, shredded and strong.

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SARMs work best when you take them in stacks. Taking them in stacks helps you with the benefit of each SARM used and gives you the best results.

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Ostarine MK 2866 and Andarine S4 stacked together and sometimes along with a low dose of Candarine GW 501516 is the one of the best bulking Stack out there. Each of the three are known to have great strength and are beneficial for both bulking and cutting. So this stack combination can also be taken for cutting. 20 m per day of Ostarine and Candarine and 25 – 30 mg per day of Andarineis the most appropriate dosage for desired results.

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Andarine and Testolone RAD 140 make a great cutting stack. Testolone is best known for its potential to give you incredible strength while Andarine aids in cutting down the unnecessary fat from your body. Both together work excellently in promoting the growth of lean muscle mass. Taking 10 mg per day of RAD 140 and 25 mg per day of Andarine S 4 will do the desired job.

Both the bulking and cutting stacks are to be taken for a 12 weeks’ duration.

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The following are the pros of using Andarine S4:

  • Effectively assists in the loss of body fat and subsequently, body weight.
  • It does not have any steroidal effects.
  • Huge increase in muscle mass and strength.
  • Increases the strength of your bones.
  • Under the recommended dosage, it is a pretty safe product to use.
  • Promotes good sexual stamina.
  • Can be stacked with other SARMs products.

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By the end of your first cycle, you gain about 10 – 12 lbs and you have already awarded yourself a beautiful body that looks muscular, strong and totally just the way you wanted to. But is also this period that the little side effects start kicking in, like lower levels of testosterone, increased fatigue and weakness and you start feeling exhausted easily plus you might notice frequent headaches and nausea.

People taking this drug in higher doses as in ranging between 40 – 75 mg per day may observe some worrisome negative side effects like alterations in vision – some may experience blurry vision while some may find it difficult to distinguish between two different colors. This might happen because overdosing on Andarine leads to the product interfering the with rods and cones components of the eye.

Overdosing on Andarine also makes the person intaking it sufferS from depression and anxiety. So it is very important you take only the recommended dose, that is, a lower one – definitely not exceeding 30 – 35 mg per day.

When taking in no matter a lower or higher dosage, all of the side effects are reversible and do not cause any permanent damage and does not damage any of your organs. Andarine interacts with the negative feedback loop of the Hypothalamic Pituitary Gonadal Axis thereby may cause imbalance and decrease in Testosterone levels. Once you start your Post Cycle Therapy, each possible side effects diminish.

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Post Cycle Therapy, abbreviated as PCT is the period where you take a type of medicinal drug to help free your body from any side effects from the previous usage of the SARMs cycle.

In case of SARMs, you do not need potent PCTs like Clomid or Nolvadex. You may go for a PCT that is mild added with a Hcgenerate ES or maybe a Selectively Estrogen Receptor Modulator (SERM).Taking any of these would do the necessary job of removing the side effects and making you feel good once again. Our team’s personal favorite is the Red PCT which is made up of only natural ingredients making it easy for your body after a 12 weeks’ SARMs cycle. The ingredients present in the PCT include Grape Seed Extract, Agaricus, Luteolin, Bisporus, DIM, Resvaratrol, Apigenin and Acacetin. All seven of these are natural extracts and are pure natural aromatase inhibitors. They are absolutely not hard on your body like strong PCTs – Clomid or Nolvadex.

This cycle continues for a time period of 4 weeks. By the end of completion of this cycle, you recognize the fit perfect body you achieved while on your SARMs cycle plus the renewed energy and a pleasant mood devoid of any side effects achieved with the help of your 4 weeks’ Post Cycle Therapy. Your hard work has paid off and it is now time you allow your body to have a rest from all the cycles. You are advised to take a 3-4 weeks break and only then you can begin your next cycle.

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Like other SARMs, Andarine is not approved by Food and Drugs Administration of America as of yet either. It is still under research and is being studied as a cure for certain types of cancer like that of the breast or the prostate gland and they are also found to be a cure for osteoporosis and other muscle degenerative disorders.

Andarine and every other SARMs are in the list of prohibited drugs by the World Anti-Doping Agency so that sportSpersons and athletes do not get superiority in performance over other competitors by using Andarine/SARMs before a game.

Andarine IS legal for clinical and medicinal research purposes and is sold in small bottles. Bodybuilders buy these bottles online. It is important that you get yourself SARMs from reliable sources so that you can be sure that the product you are buying is not contaminated. Contaminated Andarine is the reason why some users complain about harmful side effects. Pure solution of Andarine never tend to have any such detrimental irreversible effects.

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LGD 4033 is allegedly the most potent SARM on the market. It’s currently being developed to improve recovery from hip fractures, while its unofficial use remains popular among bodybuilders and those seeking appearance enhancement. Among all the hype, read our unbiased review to understand what the actual science says about its potential uses.

Disclaimer: By writing this post, we are not recommending this drug. Ligandrol is an unapproved research chemical without a complete safety profile, and we simply don’t know enough about its adverse effects or efficacy. Some of our readers who were already taking the drug requested that we commission a post on it, and we are simply providing information that is available in the clinical and scientific literature.

We do not recommend taking ligandrol for any reason.

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LGD 4033 is a fairly new oral selective androgen receptor modulator (SARM). SARMs have received a lot of attention recently, both in the medical community and among people who are seeking physical performance and appearance enhancement. Scientists are exploring the ways SARMs could be used to overcome muscle wasting and bone diseases.

Bodybuilders believe that they’re safer alternatives to steroids, but there is no data to suggest that unapproved SARMs are safe at all.

LGD 4033 is also known as Ligandrol and Anabolicum. LGD 4033 is among the two most popular SARMs when it comes to bodybuilding, MK-2866 (Ostarine) being the other.

Like all SARMs, LGD 4033 binds to androgen receptors in the muscles and bones with high affinity and selectivity. Because of this, scientists hypothesize that LGD 4033 shouldn’t affect other organs (sparing the liver, prostate, and sebaceous glands) or cause severe suppression of your natural testosterone production. Being nonsteroidal, LGD 4033 shouldn’t be converted to estrogeneither; these hypotheses are purely speculative, however, and lacking in clinical data. Future human trials may very well prove them wrong [1].

Users claim that LGD-4033 is more potent than MK-2866. Others prefer MK-2866, especially when it comes to cutting cycles. Both are favored for their perceived muscle gains, unlike steroids that can cause a long list of side effects and can harm your vital organs.

Yet, this is an unapproved drug. We do not know how safe it is, or even if it works. We highly recommend against taking Ligandrol for this reason.Ligandrol or LGD-4033 is a new SARM that’s become popular among bodybuilders but never went though proper clinical trials.

We decided to look into the reasons behind LGD 4033’s ongoing popularity and tease apart its actual effects. In this article, we review the most up-to-date research on its potential uses and provide a summary of its proposed mechanism of action.

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  • Lean muscle mass gains & increased strength
  • Fat loss
  • May help heal and strengthen bones
  • Few side effects reported in clinical trials

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  • Insufficient human research
  • Banned in professional sports
  • Long-term effects are unknown
  • May cause slight testosterone suppression
  • Not enough data to determine side effects
  • No data to suggest correct dosage

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SARMs can selectively navigate to muscles and bones. They activate androgen receptors but are chemically different from steroids. As such,they are not substrates for 5 alpha-reductase or CYP19 aromatase, which prevents their conversion to the testosterone metabolite DHT or estrogen [2]:

However, not all SARMs are equally muscle-selective. Some SARMs were abandoned due to their potential for serious side effects. On the other hand, a handful of SARMs are being developed as potential birth control pills for men since they act on the pituitary. These are all currently theoretical at this point, with research still ongoing. Some or all such substances may turn out to be ineffective or unsafe in large, high-quality studies.

The first generation SARMs (developed by Ligand Pharmaceuticals and including LGD 4033) had a modest but undeniable effect on lean body mass gains. The second generation of SARMs we are yet to see might be even more potent and selective—but, again, this is highly speculative until better-quality research is conducted [3].

Scientists are trying to understand what makes some SARMs better than others in the hopes of discovering safer and more selective drugs. Ongoing LGD 4033 research should give us additional clues in the near future.Like all SARMs, LGD-4033 is thought to bind to androgen receptors in the muscles and bones, but its effectiveness, selectiveness, and safety remain unknown.Help Protect Yourself From Coronavirus by Optimizing Your Health!

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LGD 4033 raises anabolic activity in the muscles and bones while reducing muscle wasting and bone breakdown. This is very early clinical work, and we will need much more research before we can be confident in this effect [1].

In one small, early clinical trial, LGD 4033 increased lean body mass and strength, decreased body fat, improved wellbeing, and enhanced the healing process. However, the doses and goals of clinical studies differ from its real-world use [1].

To rewind to the early research phases, both MK-2866 and LGD-4033 were developed with the goal of reducing muscle wasting in people with muscular dystrophy, the elderly, and in cancer patients. Realizing that these drugs may also increase bone strength and healing, scientists began looking into their potential to improve bone diseases such as osteoporosis.Ligandrol was developed with the aim of increasing anabolic activity and reducing muscle wasting in people with serious illnesses.

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LGD 4033 was initially created by Ligand Pharmaceuticals, hence the name “Ligandrol”. Viking Therapeutics took over LGD 4033 research in the meantime, renaming it to VK5211. This small pharma company is researching LGD 4033/VK5211 for hip fracture recovery. They state that it will hopefully produce all the benefits of testosterone with improved safety, aiming to get approval for its clinical use sometime in the future.

According to their claims, the goals of SARM therapy in people with fractures are to:

  • Increase lean body mass
  • Increase muscle and bone strength
  • Improve physical performance and quality of life

We are yet to see if LGD 4033 will gain approval based on new clinical trials or not.Some scientists have hypothesized that Ligandrol might improve fracture recovery, but this hasn’t been proven.

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Despite the research still being underway, LGD 4033 entered the bodybuilding community a while ago. It was, at first, classified as a supplement and recategorized later as a research chemical, along with all other SARMs.

The World Anti-Doping Agency banned all SARMs, including Ligandrol, under the S1 Anabolic Agent category of the Prohibited List back in 2008. With this in mind, LGD 4033 can get professional athletes into serious trouble. A couple of years ago, LGD 4033 was all over the news for getting the Florida Gators quarterback, Will Grier, suspended. Will Grier was caught for using it during a routine urine test.

Despite the negative media coverage, users are claiming that LGD 4033 is the most potent SARM on the market and the only option for serious gains without steroids. It’s rivaled only by RAD-140 (Testolone). WIthout rigorous clinical studies, however, these are only anecdotal claims; we currently have no way of knowing whether ligandrol is actually effective or safe.Ligandrol is still sold illegally, although it’s classified as a research chemical (not a supplement) and is on WADA’s prohibited list.

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Cancer patients often suffer from muscle wasting, which begins early on and can reduce the quality of life, chemotherapy tolerance, and survival. SARMs increase muscle mass and improve fitness in both healthy people and cancer patients. In light of their specificity and safety, SARMs emerged as promising new therapeutics for combating muscle breakdown [4].

According to their proponents, SARMs may target the same anabolic pathways as typical steroids but without the androgenic side-effects. Within the dose range for increasing muscle mass and function, these people say, they don’t cause detrimental effects on the prostate, skin, or hair. Again, this is currently an unproven hypothesis.

Unlike testosterone, SARMs are orally active and seem unlikely to aromatize to estrogens. Being tissue-selective, SARMs don’t cause hoarseness of the voice and other unwanted symptoms of excess male sex hormones [5].

The only clinical trial so far with LGD 4033 involved 76 healthy men, who all received escalating low doses (0.1, 0.3, and 1 mg/day). LGD 4033 was well tolerated and safe over 3 weeks and 1 mg/day was sufficient to increase lean body mass by almost 3 lbs; lower doses didn’t have an effect. LGD 4033 slightly increased leg press strength and stair climb power [1, 4].

An earlier study previously demonstrated the safety of doses up to 22 mg/day. The lower doses in the larger study, however, were estimated to maximize lean muscle gains while minimizing side effects. Note that this data came from animal studies, the purpose of which was to determine the appropriate dose for future clinical trials. Such animal studies don’t reflect the safety or effectiveness of ligandrol in humans [1].One small trial suggested that Ligandrol might increase lean body mass, hinting at its potential to reduce muscle wasting, but this has yet to be verified.

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Cachexia is a broader term than muscle wasting. It involves extreme weight loss and muscle atrophy, fatigue, and appetite loss. This wasting syndrome is common in patients with AIDS, cancer, kidney disease, sepsis, and severe burns.

The main contributors are high cytokine levels (IL-6, TNFα, IFN 1b, IFN gamma) and high levels of muscle-degrading molecules (proteolysis-inducing factor). The wasting of respiratory muscles and resulting pneumonia causes over one-third of cancer-related deaths [6].

Before scientists realized the potential benefits of SARMs for cachexia, many other drugs were studied. Anabolic steroids such as nandrolone improved cachexia, lean body mass, and bone density in some studies. However, their major drawbacks are serious side effects such as liver toxicity and masculinization in women [6].

Testosterone, on the other hand, could increase lean mass and muscle performance in HIV-infected men. On the downside, testosterone increases the risk of prostate cancer, affects the sexual organs, and causes red blood cell imbalances by raising the hematocrit [6].

Being selective, SARMs are seen as a major breakthrough for cachexia. However, not all SARMs are equally effective or safe. According to its proponents, LGD-4033 selectively and potently increases muscle mass without detrimentally affecting the prostate or hematocrit; however, no studies have yet investigated this claim [6].

By increasing muscle strength, LGD 4033 could increase survival in people with cachexia and may help them better tolerate intensive treatments (such as radio and chemotherapy) [6].SARMs like Ligandrol are thought to have potential for improving catexia (a form of extreme muscle wasting with fatigue), but clinical data are still lacking.

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Preventing bone loss and increasing bone formation are key to protecting against osteoporosis. The standard therapy for osteoporosis is far from ideal and SARMs are being researched as a safer option for increasing bone strength and bone healing.

Currently, bisphosphonate drugs are the first-line, in addition to calcium and vitamin D supplements. Bisphosphonates increase bone mineral density by inhibiting bone-degrading cells called osteoclasts. They also come with side effects that are hard to tolerate for some.

Women in menopause may be prescribed hormone replacement therapy. However, synthetic hormones such as progestins that are often part of the regimen increase the risk of breast and uterine lining (endometrial) cancer, and heart disease [6].

Activating the androgen receptors can boost bone mineral density by increasing the formation of new bones in response to injury, which is called the “periosteal reaction”. The periosteum is the connective tissue that covers the outer surface of bones [6].

The androgen receptors (AR) SARMs are crucial for maintaining bone mass and allowing for the healing of fractures. For example, mice without ARs have reduced bone mineral density (osteopenia). Men undergoing androgen deprivation therapy for longer periods of time also suffer from low bone mineral density [6].

SARMs have the potential to be used for osteoporosis in both men and women, as they don’t trigger androgen excess. The SARM S-4 completely prevented bone loss In postmenopausal rats, returning their bone mass and strength to the levels of healthy controls. It was more efficient than dihydrotestosterone (DHT) [6].

LGD 4033 studies by Viking Therapeutics are currently underway. This SARM may see approval in the future for improving recovery after hip fracture surgery. However, it’s important to understand that future work could reveal ligandrol to be either unsafe or ineffective. It’s dangerous to assume that ligandrol is safer than standard treatments with known safety profiles; a lot of drugs that showed promise in early studies turned out to be downright dangerous.Scientists hypothesize that Ligandrol might stimulate androgen receptors in the bones, potentially helping reduce bone loss. Studies will soon reveal whether it’s effective at improving recovery after hip fracture surgery.

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The effects of SARMs on the brain are still an active area of research. It’s well-known that testosterone has a large impact on psychosexual and cognitive behavior. SARMs are bone- and muscle-selective but they also cross into the brain, which helps explain why they are being studied for libido and mood enhancement [7].

It’s uncertain exactly how much SARMs affect the brain. On one hand, their effects on cognition could just be a consequence of increased muscle strength and stamina. On the other, they may, in fact, activate androgen brain receptors [3].

In support of their benefits on the brain, Viking Therapeutics claims that LGD 4033 has the potential to improve cognition, libido, and energy. Many users report an increased sense of wellbeing and stamina with this SARM.Due to a lack of research, we don’t yet know how Ligandrol might affect brain health.

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Despite some promising research, no male contraceptive pills have yet reached the market. Even with the increasing need for population control, contraceptive choices available to men are very limited [8].

Most SARMs alone couldn’t cause the hormonal changes required of a male contraceptive pill. Some SARMs are suitable candidates, as they can inhibit gonadotropins from the pituitary (FSH and LH) but spare the prostate. SARMs might also have a positive effect on libido, which would be crucial if they were to be used as male contraceptives [8, 3].

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The only proper clinical study was supported by Ligand Pharmaceuticals, who developed LGD. The ongoing studies are funded by Viking Therapeutics, a company that bought over the rights to LGD 4033 research. It’s difficult to objectively assess the quality of studies funded by pharma companies, their conflict of interest, and bias. The company-funded studies were furthermore very limited, without much of value to say about whether Ligandrol is effective or safe or what the correct dose might be.We at SelfHacked advise speaking to a doctor before taking any drug, especially an unscheduled drug with limited long-term safety data in humans.

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Ligandrol is an unapproved drug that may increase muscle size and strength. Some people believe that it has fewer side effects than conventional testosterone replacement therapy, but there isn’t currently enough data to support this idea.

Talk to your doctor about lifestyle changes or other approved strategies that may help you reach your fitness and health goals, especially since we don’t know whether ligandrol is safe.

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RAD140, also known as testolone, is a new investigational drug which has become popular among bodybuilders, who claim that it has muscle-building effects. RAD140 for sale belongs to a class of compounds called selective androgen receptor modulators, or SARMs [1].

SARMs bind to androgen receptors that are found in different areas of the body. Normally, these receptors interact with androgens, which are a group of steroid hormones. Androgens like testosterone, dihydrotestosterone, and androstenedione are naturally produced by the body [2].

SARMs and testosterone tend to have similar effects because they work on the same receptor. The intended targets of SARMs include the muscles, bones, and liver [2].

SARMs are of particular interest to researchers because they are selective about where they work. They mostly target muscle and bone tissues, and appear to have minimal effects on the prostate and other organs. Because of this, some researchers believe that SARMs could potentially treat hormone-related or muscle-wasting disorders with fewer side effects than existing treatments, but this is an unproven hypothesis without data to back it up [2].

This potential has also made SARMs a popular choice over testosterone or steroids for bodybuilders. Although testosterone and steroids boost muscle growth, they also have unwanted effects on the prostate and reproductive organs, among others [3].RAD140 (Testolone) is a SARM: it mimics testosterone but mostly targets the muscles, which some believe could potentially reduce its side effects compared to testosterone or other steroids. No data backs up this hypothesis.

Testolone is an unapproved drug that comes with a ton of warnings. Why do people use it? Learn about the risks and dangers of RAD140.

Disclaimer: While testolone is not illegal to have, it is illegal to sell and banned in professional and amateur league sports. Some of our readers who were already taking the drug requested that we commission a post on it, and we are simply providing information that is available in the clinical and scientific literature.

Testolone is an experimental drug not approved for human consumption.

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  • May increase muscle mass
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  • May suppress testosterone
  • May cause hair loss, fatigue, and mood swings
  • No human studies
  • Long-term risks are unknown
  • Safety profile and full side effects are unknown
  • Appropriate dosage are unknown

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RAD140 has become popular in men with low testosterone levels who want to avoid testosterone replacement therapy but are looking to maintain their physical and sexual performance. Such use is still completely anecdotal, without research to back it up.

In fact, without complete studies, testosterone replacement therapy remains a safer approach than using SARMs like testolone. Remember that we know nothing about the safety profile of this experimental, unapproved drug, while testosterone’s effects are well-studied and predictable.

Research is currently investigating the potential role of RAD140 in increasing muscle mass, fighting breast cancer, and protecting brain cells [1, 4, 5].

Despite the lack of safety research in humans, bodybuilders use RAD140 to increase strength and endurance. RAD140 is not illegal, but it is banned in professional sports. Along with all other SARMs, RAD140 is on the prohibited list of the World Anti-Doping Agency [6].Some athletes believe RAD140 can boost testosterone, muscle mass, and physical performance. It is banned in professional sports, and without more clinical studies, we don’t know whether it works or how safe it might be.

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RAD140 works by selectively stimulating androgen receptors in the body. It targets receptors in the muscle and bone and has had little to no observed effect on the reproductive organs [1].

This compound stimulates muscle growth by promoting the development of muscle cells and proteins [2].

The selective ability of SARMs is not fully understood yet. According to some researchers, they may target and selectively activate different proteins than testosterone. This results in only certain androgen receptors – mainly in the muscles – being activated [2].

The chemical structure of RAD140 is very different from the structure of steroid hormones like testosterone. Thus, the pathways that convert testosterone into other hormones (like estrogen) cannot act on testolone [1].

Based on a study in rats, some researchers have suggested that RAD140 could activate receptors in injured regions of the brain. In the brains of rats given RAD140, MAPK activity increased, thus protecting neurons from damage [5].RAD140 activates androgen receptors in muscles, but not in most other tissues. Some researchers believe that this reduces testolone’s potential to produce side effects (compared to testosterone or other steroids), but more research is needed.Help Protect Yourself From Coronavirus by Optimizing Your Health!

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Ostarine, also known as Enobosarm, is a popular SARM that has undergone limited testing in humans. One clinical trial has investigated ostarine’s ability to prevent the drastic weight loss (cachexia) caused by severe illnesses [7].

RAD140 and ostarine are both SARMs; some researchers have found minimal effects on the prostate and reproductive organs, but without high-quality clinical studies, we can’t know if this is truly the case [8].

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The claims below are strictly anecdotal and have not been investigated in any relevant studies.

Anecdotally, testolone and ostarine differ when it comes to their effects on muscle and fat. According to anecdotal reports from people who use SARMs, ostarine has milder muscle-building effects and is better for fat loss. It’s the usual choice for “cutting cycles” and for those that want to gain modest but lean muscle mass. On the other hand, many of these same anecdotes report that RAD140 is a stronger SARM that provides better muscle growth. It’s a more popular choice for bulking.

Remember that none of these anecdotes have ever been tested in clinical research, and they should all be taken with several large grains of salt. People’s reports of their own experience can be interesting, but they cannot replace high-quality, placebo-controlled studies conducted by experts in the field.

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RAD140 is popular in the bodybuilding community for its purported muscle-building effects. Some researchers believe that, much like other SARMs, it may increase muscle growth without the unwanted effects of conventional steroids [2].

Despite this popularity, the scientific evidence behind RAD140 is scant.

Currently, there is only one animal study that examined RAD140’s effect on muscle growth. In the study, researchers tested different doses in 9 monkeys. They found that monkeys that received RAD140 daily had increased lean muscle mass after 28 days [1].

Human studies of RAD140 have not yet been performed.RAD140 is popular in bodybuilding, but no clinical trials have examined its safety and efficacy in humans.

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Researchers are currently investigating RAD140 for potential action against breast cancer [4].

A common form of breast cancer called androgen and estrogen receptor-positive (AR/ER+) is sensitive to hormones. Medications that affect these receptors, like SARMs, may have cancer-fighting potential [9].

In a cell study, RAD140 stopped the growth of AR/ER+ breast cancer by blocking the effects of estrogen [4].

Specifically, RAD140 appears to suppress the ESR1 gene. This gene is responsible for creating estrogen receptors. Without sufficient receptors, estrogen becomes inactive [4].

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Androgens play an important role in protecting the brain. They can increase brain cell growth, improve memory, and decrease amyloid-beta accumulation. Amyloid-beta plaques are among the main causes of Alzheimer’s disease [5].

In a rat study, RAD140 protected brain nerves against injury from amyloid-beta plaques. Additionally, RAD140 and testosterone were equally effective at protecting against neurotoxins [5].

Some RAD140 users report better sleep, but there are no studies to back this effect up. Same goes for its supposed ability to enhance sexual performance – although this could be tied to its testosterone-mimicking effects.Users claim RAD140 improves sleep and sexual performance, but no studies back this up.

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Some people believe that SARMs increase muscle mass and reduce body fat.

Only one study in monkeys looked at RAD140’s effects on muscle and fat. Although it increased lean muscle, the effect on body fat was unclear [1].

The study did find that RAD140 improves cholesterol levels. Additionally, a higher muscle mass can increase energy use to further promote fat loss, but these factors did not play out to lower body fat in the single available study. Thus, there is currently no evidence that testolone promotes weight loss [1, 10].Some people believe SARMs increase muscle mass and reduce body fat, but the limited studies available don’t support this use.

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RAD140 benefits have yet to be explored in human studies. This drug has only been tested in rats and monkeys. Although it is used as a supplement by athletes, the long-term benefits and risks of human use are unknown. Testolone is an unapproved drug with very limited evidence of safety or efficacy: that is, we dont know how safe it is, or even whether it works.

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RAD140, just like all other SARMs, is banned in professional sports by the World Anti-Doping Agency. Researchers have already developed methods to detect RAD140 in drug tests [6, 11].

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SARM users should be careful when purchasing products online.

In a recent study, researchers analyzed 44 different SARM products that were sold online. They found that only 52% actually contained SARMs [12].

In addition, 39% of products contained an unapproved drug and 25% contained substances not listed on the label [12].Human studies haven’t verified the safety and efficacy of RAD140. It’s banned in professional sports and most products available online are dangerous. For this reason, we strongly recommend against taking this drug.

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RAD140 is a new investigational substance. Its safety and side effects have not been clinically evaluated yet.

Based on how SARMs work, its proponents say that RAD140 should cause fewer unwanted effects than testosterone, but this is completely unproven. RAD140 still has the potential to cause testosterone-related side effects. These may include [13, 14]:

  • Breast tenderness/growth in men
  • Abnormal body hair growth in women
  • Changes in sex drive
  • Male pattern baldness/hair loss
  • Mood swings and anxiety/depression
  • Nausea and vomiting

Bodybuilders commonly report hair loss as a side effect, which is reversed once they stop taking RAD140.Clinical trials haven’t tested the safety of RAD140 yet. Despite online claims, it may still cause hair loss and breast growth in men, changes in sex drive, and mood disorders.

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SARMs can suppress the body’s natural testosterone production. It may slightly raise blood estradiol, similar to other SARMs. Some people claim that RAD140 is special as it won’t aromatize to estrogen or shut down your testosterone, but no studies back up these claims. Plus, user reviews suggest otherwise.

In theory and in practice, RAD140 can potentially cause testosterone suppression and estrogen buildup. This can cause decreased sex drive, depression, and tiredness. Users recommend PCT (Clomid or Nolvadex) to restore hormone levels – which goes to say it’s probably not as selective as some advocates claim.

The degree of suppression or estrogen-like effects can vary – some users report being more sensitive to it, while it doesn’t impact others as much. Greater doses and longer use of any substances will always increase your risk of unwanted effects, and RAD140 is no exception.

There is currently no way of knowing all the potential side effects of testolone because of the lack of clinical studies. This is only one of the many reasons we strongly recommend against taking RAD140.RAD140 may suppress testosterone and increase estrogen, leading to reduced sex drive, depression, and fatigue. Long-term use of higher doses increases your risk of side effects.

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One of the biggest drawbacks of using testosterone is the negative effects it has on the prostate. Testosterone enlarges the prostate and potentially increase the risk of prostate cancer [15].

The selective nature of SARMs means that they should have little to no effect on the prostate. Based on current research, RAD140 does not seem to increase the size of the prostate. However, research has not been done in humans yet, and many users have reported experiences that contradict the supposed selective benefits of testolone. Full scale clinical studies could very well find adverse effects on the prostate [1, 5].

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There is no set dose for RAD140, as it hasnt been investigated in humans. Until and unless clinical studies sufficiently explore this drug, in context and for a specific purpose, a safe dosage does not exist.

Bodybuilding resources usually recommend a dosage of 10 to 30 mg per day for men and 5 to 10 mg per day for women.

Users typically cycle RAD140 for 8 to 12 weeks. The off-cycle can vary: some recommend they last as long as the cycles, while others think that a shorter off-cycle of 6-8 weeks is sufficient.

Veterans will tailor these depending on their labs, checking to see how the cycles affected their liver markers and hormone balance.

These doses are purely speculative and not backed up by scientific research.

RAD140 appears to have good bioavailability. According to research in monkeys, about 70% of the drug is absorbed into the body when ingested [1].Due to the lack of clinical trials, there’s no established RAD140 dosage. Bodybuilders usually cycle it over 8-12 weeks at 10-30 mg/day (5-10 /day for women). No scientific research backs up these doses.

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In order to increase results, bodybuilders will sometimes combine RAD140 with other SARMs or steroids. Users have reported “stacking” with ostarine, ibutamoren, and conventional steroids like Primobolan. The combination with ostarine is reported to improve recovery. For cutting or endurance gains, it’s usually stacked with cardarine.

We cannot stress this enough: these stacks are very dangerous. Each of these drugs is unapproved and insufficiently studied. None of them have complete safety profiles. We strongly recommend against taking any single one of these substances, let alone two or three at once.

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The use of SARMs and steroids can suppress the body’s ability to produce testosterone. Most experienced users recommend post-cycle therapy (PCT) after each cycle of RAD140 [14].

PCT usually involves taking Nolvadex and Clomid to restore hormone levels. The optimal length of PCT can vary depending on the length of SARM use. Users typically report taking PCT for 3 to 4 weeks.Users often stack RAD140 with other SARMs or steroids. Most of them recommend PCT with Nolvadex and Clomid for 3 to 4 weeks after each cycle. However, without real clinical studies, there is no safe way of taking these substances.

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Many online users believe that this compound is a safer alternative to testosterone replacement therapy. They cite anecdotal reports and theories that have no supporting data or studies of any kind to investigate them.

Based on anecdotal reports of adverse side effects, the lack of clinical studies, and the dearth of available data, we believe that testosterone replacement therapy – under the supervision of a licensed physician – remains a much safer alternative to taking this, or any, SARM.

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Patients with hormonal imbalances or deficiencies should approach the use of RAD140 with caution [16].

Mutations in the gene coding for the androgen receptor may change the body’s response to RAD140. Depending on the mutation, RAD140 can have increased or decreased activity in the body. People with variations in this gene may also be susceptible to more side effects with RAD140. However, this has yet to be researched in more detail [16, 17].

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As an unapproved drug used as a supplement by bodybuilders, people say they think that RAD140 is great for increasing muscle mass while also reducing body fat. Some believe it also improves speed, stamina, and endurance during exercise.

Users also report that RAD140 works quickly, with evident results in as little as 3 to 4 weeks.

RAD140 tends to cause testosterone suppression and most users opt-in for PCT after.

Side effects reported by users include hair loss, tiredness, and decreased sex drive. Others have experienced mood changes and joint pain. A few users who do lab tests after cycles had high liver markers (ALT and AST) after taking RAD140.

We at SelfDecode advise speaking to a doctor before taking any drug, especially an unscheduled drug with limited long-term safety data in humans.

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RAD140 is an investigational drug popular for its muscle-building action. It is a SARM that may increase muscle mass. Research is currently exploring RAD140’s effects on health, as its safety, efficacy, side effects, and long-term risks in humans are unknown. Side effects commonly reported by users include temporary hair loss, decreased sex drive, and mood changes. Like all SARMs, RAD140 is banned (and actively screened for) in professional sports. Users should also be cautious when purchasing SARMs online; many products do not contain the advertised ingredients. Based on the available evidence, a lack of human studies demonstrating safety and efficacy, and anecdotal reports of adverse effects, we do not recommend using testolone. Physician-supervised testosterone replacement therapy is a better approach than untested SARMs.